480-36-4

Basic information

• Product Name: Linarin
• Synonyms: LINARIN;BUDDLEOSIDE;BUDDLOSIDE;ACACETIN-7-O-RUTINOSIDE;ACACETIN-7-RUTINOSIDE;7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5-hydroxy-4'-methoxyflavone;7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)-4H-benzopyran-4-one;Buddloside，Linarin
• CAS NO: 480-36-4
• Molecular Formula: C₂₈H₃₂O₁₄
• Molecular Weight: 592.55
• EINECS: 207-547-6
• Product Categories: Tri-substituted Flavones;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 480-36-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 258-260°C
• Boiling Point: 885.2 °C at 760 mmHg
• Flash Point: 292.2 °C
• Appearance: /
• Density: 1.62 g/cm³
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Acetic Acid (Very Slightly, Heated), Acetonitrile (Slightly), DMSO (Slightly), M
• PKA: 6.11±0.40(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: Linarin(CAS DataBase Reference)
• NIST Chemistry Reference: Linarin(480-36-4)
• EPA Substance Registry System: Linarin(480-36-4)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 480-36-4(Hazardous Substances Data)

Usage

Description

Linarin, also known as Diosmin EP Impurity E, is a naturally occurring flavone glycoside found in various plant sources. It is characterized by its potential sedative and anticonvulsant properties, making it a promising candidate for pharmaceutical applications.

Uses

Used in Pharmaceutical Applications:
Linarin is used as a sedative agent for its potential calming effects on the central nervous system. Its ability to induce a state of relaxation and reduce anxiety makes it a valuable component in the development of medications aimed at treating stress-related disorders and promoting overall mental well-being.
Additionally, Linarin is used as an anticonvulsant agent for its potential to prevent or reduce the severity of seizures. Its anticonvulsant properties can be beneficial in the treatment of various conditions characterized by abnormal electrical activity in the brain, such as epilepsy and other seizure disorders.
Used in Nutraceutical Applications:
Linarin can also be utilized in the development of nutraceutical products, such as dietary supplements and functional foods, due to its potential health benefits. Its sedative and anticonvulsant properties may contribute to the overall wellness of individuals seeking natural alternatives for stress management and seizure control.

Upstream product

• 480-44-4 5,7-dihydroxy-2-(4'-methoxyphenyl)-4H-1-benzopyran-4-one 
• 4154-21-6 O²,O³,O⁴-triacetyl-O⁶-(tri-O-acetyl-α-L-rhamnopyranosyl)-α-D-glucopyranosyl bromide 
• 771480-96-7 3'-O-(1-phenyltetrazol-5-yl)diosmin 
• 520-27-4 diosmin 

Downstream Products

• 124904-19-4 linarin heptaacetate 
• 480-44-4 5,7-dihydroxy-2-(4'-methoxyphenyl)-4H-1-benzopyran-4-one 
• 50848-66-3 7,4'-dimethoxy-5-hydroxy-6-iodoflavone 
• 5128-44-9 5-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one 
• 827346-51-0 C₂₈H₃₁BrO₁₄ 

Relevant articles and documents

Semisynthesis of linarin, acacetin, and 6-iodoapigenin derivatives from diosmin

Semisynthesis of linarin and acacetin from the Citrus flavonoid diosmin was performed via, as first intermediate, the 3′-O-phenyltetrazolyl ether of diosmin. This paper relates also a semisynthetic access to 6-iodoapigenin derivatives, which are key compounds in the synthesis of some biflavonoids such as robustaflavone.