480-54-6 Usage
Description
RETRORSINE is a primary reference substance with assigned absolute purity, taking into account chromatographic purity, water, residual solvents, and inorganic impurities. The exact purity value can be found on the certificate provided by PhytoLab GmbH & Co. KG.
Uses
Used in Pharmaceutical Industry:
RETRORSINE is used as a reference substance for quality control and standardization in the pharmaceutical industry. Its assigned absolute purity makes it a reliable and consistent benchmark for various analytical and research applications.
Used in Research and Development:
RETRORSINE serves as a valuable tool in research and development, particularly in the fields of chemistry, biology, and pharmacology. Its purity and consistency allow scientists to accurately assess the performance of new compounds and formulations, ensuring the reliability of experimental results.
Used in Quality Control:
In the quality control process, RETRORSINE is used as a reference material to verify the accuracy and precision of analytical instruments and methods. This helps to ensure that the products being tested meet the required standards and specifications.
Used in Chromatography:
RETRORSINE is utilized in chromatographic techniques as a reference compound to evaluate the performance of the chromatographic system, including its separation efficiency, resolution, and peak shape. This is crucial for the accurate identification and quantification of target compounds in complex samples.
Used in Environmental Testing:
In environmental testing, RETRORSINE can be employed as a reference substance to assess the effectiveness of pollution control measures and to monitor the presence of specific contaminants in various environmental matrices, such as air, water, and soil.
Used in Material Science:
RETRORSINE may also be used in material science applications, where its purity and consistency can help in the development and characterization of new materials, as well as in the evaluation of the performance of existing materials under various conditions.
Used in Education and Training:
As a primary reference substance, RETRORSINE is an essential tool in educational and training programs related to chemistry, biology, and pharmacology. It provides students and researchers with a reliable standard for learning and practicing various analytical techniques and methodologies.
Safety Profile
Poison by ingestion, intraperitoneal, and intravenous routes. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. hhtation data reported. When heated to decomposition it emits toxic fumes of NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 480-54-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 0 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 480-54:
(5*4)+(4*8)+(3*0)+(2*5)+(1*4)=66
66 % 10 = 6
So 480-54-6 is a valid CAS Registry Number.
InChI:InChI=1/C18H25NO6/c1-3-12-8-11(2)18(23,10-20)17(22)24-9-13-4-6-19-7-5-14(15(13)19)25-16(12)21/h3-4,11,14-15,20,23H,5-10H2,1-2H3/b12-3-/t11-,14-,15-,18-/m1/s1
480-54-6Relevant articles and documents
Pyrrolizidine Alkaloid Biosynthesis. Synthesis of 3H-Labelled Trachelanthamidine and Isoretronecanol and their Incorporation into Three Pyrrolizidine Bases (Necines)
Kunec, Ellen K.,Robins, David J.
, p. 1437 - 1441 (2007/10/02)
(+/-)-Isoretronecanol (22) and (+/-)-trachelanthamidine (24) were prepared by 1,3-dipolar cycloaddition of N-formylproline with ethyl propiolate followed by reduction steps.These 3H-labelled 1-hydroxymethylpyrrolizidines together with putrescine were fed to Senecio isatideus which produces retrorsine (1); S. pleistocephalus which yields rosmarinine (8); and Cynoglossum officinale which affords echinatine (5).The double labelling experiments demonstrated that isoretronecanol is incorporated much more efficiently into rosmarinine than into retrorsine or echinatine, whereas trachelanthamidine is a much more efficient precursor for retrorsine and echinatine.Base hydrolysis of retrorsine and echinatine labelled with trachelanthamidine and of rosmarinine labelled with isoretronecanol established that most of the 3H-label was in the base portions, retronecine (2), heliotridine (6), and rosmarinecine (9), respectively.Further degradation of retronecine and rosmarinecine showed that most of the radioactivity was confined to the β-alanine (4) portion.The biosynthetic pathways to isoretronecanol and trachelanthamidine apparently diverge prior to the formation of these 1-hydroxymethylpyrrolizidines, probably during the cyclisation of an immonium ion (14) to form the 1-formylpyrrolizidines (15) and (17).
