480-91-1

Basic information

• Product Name: ISOINDOLIN-1-ONE
• Synonyms: ISOINDOLIN-1-ONE;1,3-Dihydro-2H-isoindole-1-one;2,3-Dihydro-1H-isoindol-1-one;2H-Isoindol-1(3H)-one;1H-isoindol-1-one, 2,3-dihydro-;2,3-dihydroisoindol-1-one;Isoindolin-1-One(WX619030)
• CAS NO: 480-91-1
• Molecular Formula: C₈H₇NO
• Molecular Weight: 133.15
• Mol File: 480-91-1.mol
• Article Data: 15

Chemical Properties

• Melting Point: 149.0 to 153.0 °C
• Boiling Point: 337°C(lit.)
• Flash Point: 220.2 °C
• Appearance: /
• Density: 1.1475 (rough estimate)
• Vapor Pressure: 5.37E-06mmHg at 25°C
• Refractive Index: 1.5282 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.86±0.20(Predicted)
• CAS DataBase Reference: ISOINDOLIN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: ISOINDOLIN-1-ONE(480-91-1)
• EPA Substance Registry System: ISOINDOLIN-1-ONE(480-91-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 480-91-1(Hazardous Substances Data)

Usage

Description

ISOINDOLIN-1-ONE, also known as 2,3-dihydro-1H-isoindole with an oxo group at position 1, is a member of the isoindole class of compounds. It is characterized by its off-white powder appearance and is a promising chemical intermediate for various applications due to its unique chemical structure.

Uses

Used in Pharmaceutical Industry:
ISOINDOLIN-1-ONE is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, ISOINDOLIN-1-ONE serves as a key building block for creating a wide range of organic compounds. Its versatile structure enables the formation of various derivatives, which can be utilized in different industries.
Used in Research and Development:
ISOINDOLIN-1-ONE is also used in research and development for studying its properties and potential applications. Its unique chemical structure makes it an interesting candidate for exploring new reactions and developing novel compounds with specific functionalities.

InChI:InChI=1/C8H7NO/c10-8-7-4-2-1-3-6(7)5-9-8/h1-4H,5H2,(H,9,10)

Upstream product

• 85-44-9 phthalic anhydride 
• 136918-14-4 phthalimide 
• 6587-24-2 methyl 2-cyanobenzoate 
• 4646-69-9 benzocyclopropene 
• 4083-64-1 Tosyl isocyanate 
• 2845-62-7 benzenesulphonyl isocyanate 
• 55740-90-4 2-(1-phenylvinyl)isoindolin-1-one 
• 3839-22-3 2-cyanobenzoic acid 
• 64-17-5 ethanol 
• 7664-93-9 sulfuric acid 
• 7732-18-5 water 
• 5415-18-9 2,3-Dihydro-2-nitroso-1H-isoindol-1-on 
• 611-31-4 1H-2,3-benzoxazin-1-one 
• 64-19-7 acetic acid 

Downstream Products

• 49619-49-0 3-ethoxy-1H-isoindole 
• 496-12-8 isoindoline 
• 5415-18-9 2,3-Dihydro-2-nitroso-1H-isoindol-1-on 
• 119-39-1 phthalazone 
• 25672-97-3 2-(aminomethyl)-benzoic acid 
• 141405-51-8 C₁₇H₁₁NO₃ 
• 464-72-2 tetraphenylethane-1,2-diol 
• 82480-87-3 3-(hydroxydiphenylmethyl)isoindolin-1-one 
• 88073-08-9 2-(2-phenyl-1-hydroxy-2-oxoethyl)-2,3-dihydro-1H-isoindol-1-one 
• 88883-66-3 2-(3-Isochinolinyl)-benzoesaeuremethylester 
• 88883-65-2 2-(3-Isochinolinyl)-benzoesaeure 
• 88883-63-0 6,7-Dihydro-7-hydroxy-isoindolo<2,1-b>isochinolin-5-on 
• 50707-35-2 2-benzoyl-2,3-dihydro-isoindol-1-one 
• 37993-76-3 3-phenylisoquinoline 

Relevant articles and documents

The ninhydrin core as carbonyl source to access 2-(2′-hydroxyaryl)benzimidazoles exploiting the ortho selectivity of ninhydrin-phenol adducts

Although ninhydrin is an essential analytical tool in biochemical and forensic sciences, for the past several years, it has been employed as efficient building block for diverse organic scaffolds. In the present work, the ortho selectivity of ninhydrin-phenol adducts has been exploited to obtain 2-(2′-hydroxyaryl)benzimidazoles which are well known excited state intramolecular proton transfer (ESIPT) fluorophores. Under acidic condition, 3-(2-hydroxyaroyl)isoindolin-1-one intermediate generated in situ from ninhydrin-phenol adducts was treated with o-phenylenediamine resulting benzimidazole scaffolds via a two-step one pot strategy.

Construction of a turn-on probe for fast detection of H2S in living cells based on a novel H2S trap group with an electron rich dye

A turn-on probe (ANR) for fast detection of H2S is constructed based on a 2-(azidomethyl)-4-nitrobenzoate moiety as a trap group. This group is very effective for the design of H2S probes especially with electron rich dyes. The potential biological applications of ANR were proved by employing it for fluorescence imaging of H2S in living cells.

Reaction of 1-ethoxyisoindole with maleimide and its derivatives

We have reported1 the possibility of conducting the Diels-Alder [4+2]-cycloaddition reaction with isoindoles that exist predominantly in the isoindoline form, due to the Curtin-Hammet principle. Pursuing our research, we used 1-ethoxyisoindole as the most evident analog of 1-aminoisoindole. This compound is a typical simple isoindole existing chiefly as the isoindoline tautomer. We have studied the reactions of 1-ethoxyisoindoles with maleimide and its derivatives as active dienophiles. In addition, this paper describes the synthesis of a novel compound - tri-(2-methoxycarbonyl)benzylamine.