480449-99-8

Basic information

• Product Name: 3-HYDROXY-CYCLOBUTANECARBOXYLIC ACID BENZYL ESTER
• Synonyms: 3-HYDROXY-CYCLOBUTANECARBOXYLIC ACID BENZYL ESTER;benzyl 3-hydroxycyclobutanecarboxylate;3-Hydroxy-cyclobutanecarboxylic acid benzyl este;Cyclobutanecarboxylic acid, 3-hydroxy-, phenylMethyl ester;benzyl 3-hydroxycyclobutane-1-carboxylate;Benzyl 3-hydroxycyclobutanecarboxylate - B10561
• CAS NO: 480449-99-8
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 206.24
• Mol File: 480449-99-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 326.2 °C at 760 mmHg
• Flash Point: 137.8 °C
• Appearance: /
• Density: 1.240
• Vapor Pressure: 8.92E-05mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-HYDROXY-CYCLOBUTANECARBOXYLIC ACID BENZYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-HYDROXY-CYCLOBUTANECARBOXYLIC ACID BENZYL ESTER(480449-99-8)
• EPA Substance Registry System: 3-HYDROXY-CYCLOBUTANECARBOXYLIC ACID BENZYL ESTER(480449-99-8)

Safety Data

• Hazardous Substances Data: 480449-99-8(Hazardous Substances Data)

Usage

General Description

3-hydroxy-cyclobutanecarboxylic acid benzyl ester is a chemical compound with the molecular formula C12H14O3. It is an ester derivative of 3-hydroxy-cyclobutanecarboxylic acid and is commonly used in organic synthesis and pharmaceutical research. It is a colorless liquid with a fruity odor, and it is known for its potential applications in the development of new pharmaceutical drugs and active ingredients. The compound is also used in the production of various industrial products, such as adhesives, coatings, and plastics. Overall, 3-hydroxy-cyclobutanecarboxylic acid benzyl ester has a wide range of uses and is a valuable component in chemical and pharmaceutical research and development.

InChI:InChI=1/C12H14O3/c13-11-6-10(7-11)12(14)15-8-9-4-2-1-3-5-9/h1-5,10-11,13H,6-8H2

Upstream product

• 198995-91-4 benzyl 3-oxocyclobutane-1-carboxylate 
• 100-39-0 benzyl bromide 
• 23761-23-1 3-oxocyclobutanecarboxylic acid 
• 501-53-1 benzyl chloroformate 
• 100-51-6 benzyl alcohol 

Downstream Products

• 194788-10-8 cis-3-hydroxycyclobutylcarboxylic acid 
• 480450-01-9 benzyl 3-methoxycyclobutanecarboxylate 
• 1366657-86-4 benzyl 3-phenoxycyclobutane-1-carboxylate 
• 1263284-46-3 3-phenoxycyclobutanecarboxylic acid 
• 1366660-53-8 2-N-methyl-6-[5-(3-phenoxycyclobutyl)-1,2,4-oxadiazol-3-yl]-2-N-phenyl-1,3,5-triazine-2,4-diamine 
• 1417617-98-1 benzyl 3-{4-[5-(2-fluorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}cyclobutanecarboxylate 
• 128041-58-7 cis-benzyl 3-hydroxycyclobutanecarboxylate 
• 128041-58-7 trans-benzyl 3-hydroxycyclobutanecarboxylate 
• 1438249-52-5 benzyl 3-{[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]oxy}cyclobutanecarboxylate 
• 1438250-68-0 benzyl 3-({5-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-2,3'-bipyridin-6'-yl}oxy)cyclobutanecarboxylate 
• 929913-27-9 benzyl 3-((methylsulfonyl)oxy)cyclobutanecarboxylate 

Relevant articles and documents

Investigating Bicyclobutane-Triazolinedione Cycloadditions as a Tool for Peptide Modification

Acyl bicyclobutanes are shown to engage in strain-promoted cycloaddition reactions with a diverse array of triazolinedione reagents. The synthesis of an orthogonally protected urazole building block enabled the facile preparation of amino acid- and peptid

1-(CYCLOALKYL-CARBONYL)PROLINE DERIVATIVE

A compound represented by formula (1) (in the formula: ring-D represents a three- to eight-membered hydrocarbon ring; Ra represents an optionally substituted amino C1-6 alkyl group or the like; Rb1 and Rb2 each independently represent a hydrogen atom, a halogen atom, or the like; Rc represents an optionally substituted C6-10 aryl group or the like; Rd represents a hydrogen atom or the like; and ring-Q represents a (hetero)aryl group or the like which may be substituted with a carboxyl group or the like) or a pharmaceutically acceptable salt thereof exhibits an excellent FXIa inhibitory activity, and is useful as a therapeutic agent against thrombosis or the like.

IMIDAZOLE DERIVATIVES

Disclosed herein are novel imidazole derivative compounds i.e., benzimidazole and aza-benzimidazole derivatives that act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperiipidemia, diabetes mellitus and obesity. Further disclosed are methods of treating various DGAT1 -related diseases, and the use of such imidazole compounds as described herein in the manufacture of a medicament for such treatment.