48074-47-1

Basic information

• Product Name: TETRAISOPROPYL VINYLIDENE DIPHOSPHONATE
• Synonyms: TETRAISOPROPYL VINYLIDENE DIPHOSPHONATE;VDPE;Vinylidene-1,1-diphosphonic acid tetraisopropyl ester
• CAS NO: 48074-47-1
• Molecular Formula: C₁₄H₃₀O₆P₂
• Molecular Weight: 356.33
• Mol File: 48074-47-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 412.8°Cat760mmHg
• Flash Point: >110℃
• Appearance: /
• Density: 1.08g/cm³
• Vapor Pressure: 1.2E-06mmHg at 25°C
• Refractive Index: 1.44
• CAS DataBase Reference: TETRAISOPROPYL VINYLIDENE DIPHOSPHONATE(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAISOPROPYL VINYLIDENE DIPHOSPHONATE(48074-47-1)
• EPA Substance Registry System: TETRAISOPROPYL VINYLIDENE DIPHOSPHONATE(48074-47-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 48074-47-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H30O6P2/c1-10(2)17-21(15,18-11(3)4)14(9)22(16,19-12(5)6)20-13(7)8/h10-13H,9H2,1-8H3

Upstream product

• 1660-95-3 Tetraisopropyl methylenediphosphonate 
• 4410-92-8 N,N'-diethylmethanediamine 
• 50-00-0 formaldehyd 

Downstream Products

• 1192135-70-8 C₂₄H₄₄N₂O₆P₂ 
• 1192135-63-9 C₂₄H₄₄N₂O₇P₂ 
• 1192135-61-7 C₂₀H₃₇NO₇P₂ 

Relevant articles and documents

Polyethylenimine-Bisphosphonate-Cyclodextrin Ternary Conjugates: Supramolecular Systems for the Delivery of Antineoplastic Drugs

Bisphosphonates (BPs) are bone-binding molecules that provide targeting capabilities to bone cancer cells when conjugated with drug-carrying polymers. This work reports the design, synthesis, and biological evaluation of polyethyleneimine-BP-cyclodextrin (PEI-BP-CD) ternary conjugates with supramolecular capabilities for the loading of antineoplastic drugs. A straightforward, modular, and versatile strategy based on the click aza-Michael addition reaction of vinyl sulfones (VSs) allows the grafting of BPs targeting ligands and βCD carrier appendages to the PEI polymeric scaffold. The in vitro evaluation (cytotoxicity, cellular uptake, internalization routes, and subcellular distribution) for the ternary conjugates and their doxorubicin inclusion complexes in different bone-related cancer cell lines (MC3T3-E1 osteoblasts, MG-63 sarcoma cells, and MDA-MB-231 breast cancer cells) confirmed specificity, mitochondrial targeting, and overall capability to mediate a targeted drug transport to those cells. The in vivo evaluation using xenografts of MG-63 and MDA-MB-231 cells on mice also confirmed the targeting of the conjugates.

SYNTHESIS OF TETRAISOPROPYL VINYLIDENEDIPHOSPHONATE

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Synthesis of Ethenylidenebis(phosphonic acid) and Its Tetraalkyl Esters

A new method for the preparation of tetraalkyl ethenylidenebis(phosphonates) has been developed.This two-step procedure involves the base-catalyzed reaction of a methylenebis(phosphonate) ester with paraformaldehyde followed by acid-catalyzed elimination of methanol.The effects of variations in the reaction conditions of the first step of this process are described.Ethenylidenebis(phosphonate) esters can be converted to the free acid by reaction with bromotrimethylsilane.