4812-20-8 Usage
Description
2-Isopropoxyphenol is a metabolite of propoxur, a pesticide, and is characterized by its clear light yellow to light red-brown liquid appearance. It plays a significant role in the analysis and monitoring of pesticide exposure and its potential health effects.
Uses
Used in Environmental and Occupational Health:
2-Isopropoxyphenol is used as a target chemical for developing methods to measure urinary phenolic metabolites of pesticides. This application is crucial for assessing the extent of pesticide exposure in various populations, including agricultural workers and residents living near agricultural areas, and for understanding the potential health risks associated with such exposure.
Used in Analytical Chemistry:
In the field of analytical chemistry, 2-Isopropoxyphenol serves as a reference compound for the development and validation of analytical techniques and methods. These methods are essential for the accurate detection and quantification of pesticide metabolites in biological samples, such as urine, which can provide valuable information on the exposure levels and potential health impacts of these chemicals.
Used in Toxicology Research:
2-Isopropoxyphenol is used as a model compound in toxicological research to study the metabolic pathways and toxic effects of propoxur and other related pesticides. This information is vital for understanding the mechanisms of pesticide toxicity and for developing strategies to mitigate the adverse health effects associated with pesticide exposure.
Used in Regulatory Compliance:
2-Isopropoxyphenol is utilized in the development of regulatory standards and guidelines related to pesticide exposure and safety. By establishing methods to accurately measure and monitor the levels of this metabolite in biological samples, regulatory agencies can better assess the effectiveness of their policies and interventions in protecting public health and the environment from the potential risks of pesticide exposure.
Check Digit Verification of cas no
The CAS Registry Mumber 4812-20-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,1 and 2 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4812-20:
(6*4)+(5*8)+(4*1)+(3*2)+(2*2)+(1*0)=78
78 % 10 = 8
So 4812-20-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H12O2/c1-7(2)11-9-6-4-3-5-8(9)10/h3-7,10H,1-2H3
4812-20-8Relevant articles and documents
METHOD FOR PREPARING P-HYDROXYMANDELIC COMPOUNDS IN STIRRED REACTORS
-
, (2017/07/14)
The process allows the preparation of a p-hydroxymandelic compound, comprising at least one step of condensation of at least one aromatic compound bearing at least one hydroxyl group and whose para position is free, with glyoxylic acid, the condensation reaction being performed in at least one reactor equipped with at least one mixing means, the specific mixing power being between 0.1 kW/m3 and 15 kW/m3. In addition, the invention also relates to a process for preparing a 4-hydroxyaromatic aldehyde by oxidation of this p-hydroxymandelic compound.
Chemoenzymatic total syntheses of ribisins A, B, and D, polyoxygenated benzofuran derivatives displaying NGF-potentiating properties
Lan, Ping,Banwell, Martin G.,Willis, Anthony C.
, p. 2829 - 2842 (2014/05/06)
Total syntheses of the structures, 1, 2, and 4, assigned to the biologically active natural products ribisins A, B, and D, respectively, have been achieved using the microbially derived and enantiomerically pure cis-1,2-dihydrocatechol 5 as starting material. Key steps include Suzuki-Miyaura cross-coupling, intramolecular Mitsunobu, and tandem epoxidation/rearrangement reactions. As a result of these studies, the structures of ribisins A and D have been confirmed while that of congener B was shown to be represented by 31 rather than 2.
Facile and sensitive spectrophotometric determination of propoxur in formulations and environmental samples
Kumar, Kailasa Suresh,Suvardhan, Kanchi,Rekha, Dasari,Jayaraj,Chiranjeevi, Pattium
, p. 1022 - 1027 (2007/10/03)
A facile, rapid, and sensitive spectrophotometric method for the determination of propoxur in insecticidal formulations, fortified water, vegetables, agricultural wastewater, and agricultural soil samples has been elaborated. The proposed method is based on the hydrolysis of propoxur under basic conditions, followed by instantaneous azo coupling of the resulting 2-isopropoxyphenol with the anilines 2a - c. This yielded the orange-red chromophore 3a (λmax = at 470 nm). the pale-red coupling product 3b (490 nm), or the red derivative 3c (478 nm), which are stable for 46 h, 38 h, and 24 h, respectively, and could be readily analyzed spectrophotometrically.