481630-48-2

Basic information

• Product Name: 1-benzyl-4-bromo-indole
• Synonyms: 1-benzyl-4-bromo-indole;1-benzyl-4-broMo-1H-indole
• CAS NO: 481630-48-2
• Molecular Formula: C₁₅H₁₂BrN
• Molecular Weight: 286
• Mol File: 481630-48-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 425.292 °C at 760 mmHg
• Flash Point: 211.009 °C
• Appearance: /
• Density: 1.351 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-benzyl-4-bromo-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-bromo-indole(481630-48-2)
• EPA Substance Registry System: 1-benzyl-4-bromo-indole(481630-48-2)

Safety Data

• Hazardous Substances Data: 481630-48-2(Hazardous Substances Data)

Usage

Classification

Indole class of organic compounds

Structure

Benzyl group attached to the fourth position of the indole ring, with a bromine atom at the same position

Applications

Organic synthesis, pharmaceutical research, building block for synthesis of bioactive molecules

Potential

Exhibits biological activity, used in drug development and pharmaceutical production

Versatility

Diverse reactivity, can be used as precursor or intermediate in the production of various chemical products

Upstream product

• 52488-36-5 4-bromo-1H-indole 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 

Downstream Products

• 481630-63-1 1-benzyl-4-(4-(trifluoromethoxy)phenyl)-1H-indole 
• 481630-49-3 1-Benzyl₄-[4-(trifluoromethyl)phenyl]-1H-indole 
• 1314147-44-8 4-N-acetylamino-1-benzylindole 
• 1314147-60-8 C₂₄H₂₉N₃O₂ 
• 1371591-94-4 1-(2-(1-benzyl-4-bromoindol-3-yl)phenyl)ethanone 
• 1371591-98-8 2-benzyl-2,6-dihydro-2-aza-dibenzo[cd,h]azulen-7-one 
• 1371592-17-4 2-benzyl-6-phenyl-2,6-dihydro-2-aza-dibenzo[cd,h]azulen-7-one 
• 1371592-21-0 2-benzyl-6-(3-methoxyphenyl)-2,6-dihydro-2-aza-dibenzo[cd,h]-azulen-7-one 
• 1371592-22-1 2-benzyl-6-pyridin-3-yl-2,6-dihydro-2-aza-dibenzo[cd,h]azulen-7-one 
• 1371591-84-2 1-benzyl-4-bromo-3-iodoindole 
• 1404580-93-3 1-benzyl-4-bromo-3,3-difluoroindolin-2-one 

Relevant articles and documents

Rationally designed N-phenylsulfonylindoles as a tool for the analysis of the non-basic 5-HT6R ligands binding mode

Among all of the monoaminergic receptors, the 5-HT6R has the highest number of non-basic ligands (approximately 5% of compounds stored in 25th version of ChEMBL database have the strongest basic pKa below 5, calculated using the Instant JChem c

The palladium-catalyzed direct C3-cyanation of indoles using acetonitrile as the cyanide source

The ligand-free palladium-catalyzed C3-cyanation of indoles via direct C-H functionalization was achieved. This protocol, utilizing CH3CN as a green and readily available cyanide source, produced the desired products in moderate to good yields through transition-metal-catalyzed C-CN bond cleavage. This journal is

Synthesis of tetracyclic indoles via intramolecular α-arylation of ketones

Figure Persented: An intramolecular palladium(0)-mediated α-arylation of ketones applied to the synthesis of various substituted tetracyclic indoles is reported. Most significantly, the efficiency of the transformation was enhanced by the use of monoligated Pd(0) complexes. This methodology was extended to double α-arylation of ketones using one-pot reactions with either simultaneous addition or sequential addition of two aryl halides for producing aryl substituted tetracyclic indoles.