482-25-7

Basic information

• Product Name: BYAKANGELICIN
• Synonyms: Biacangelicin;Bjacangelicin;Bjakangelicin;Byankagelicine;9-[(2R)-2,3-dihydroxy-3-methyl-butoxy]-4-methoxy-furo[3,2-g]chromen-7-one;9-[(2R)-2,3-dihydroxy-3-methylbutoxy]-4-methoxyfuro[3,2-g]chromen-7-one;BYAKANGELICIN (P);5-Methoxy-8-(2,3-dihydroxy-3-methylbutoxy)psoralene
• CAS NO: 482-25-7
• Molecular Formula: C₁₇H₁₈O₇
• Molecular Weight: 334.32062
• Mol File: 482-25-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 123-124℃
• Boiling Point: 571.5°Cat760mmHg
• Flash Point: 299.4°C
• Appearance: /
• Density: 1.373
• Vapor Pressure: 6.69E-14mmHg at 25°C
• Refractive Index: 1.613
• Storage Temp.: ?20°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 13.67±0.20(Predicted)
• CAS DataBase Reference: BYAKANGELICIN(CAS DataBase Reference)
• NIST Chemistry Reference: BYAKANGELICIN(482-25-7)
• EPA Substance Registry System: BYAKANGELICIN(482-25-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 482-25-7(Hazardous Substances Data)

Usage

Description

BYAKANGELICIN, also known as (+)-Byakangelicin, is a naturally occurring compound derived from plants in the genus Angelica. It possesses various biological activities and has been found to have potential applications in the pharmaceutical and medical fields due to its unique properties.

Uses

Used in Pharmaceutical Applications:
BYAKANGELICIN is used as an inhibitor of sex hormones, affecting the catabolism of endogenous hormones. This property makes it a potential candidate for the development of drugs targeting hormone-related conditions.
Used in Hepatocyte Applications:
BYAKANGELICIN directly affects the cytochrome P450 isoform (CY) P3A4 in human hepatocytes, which is an essential enzyme involved in the metabolism of various drugs and substances in the liver. This interaction with CYP3A4 can be utilized in the development of drugs that modulate the activity of this enzyme, potentially improving the efficacy and safety of certain medications.
Used in Diabetic Complications Treatment:
BYAKANGELICIN is used as an inhibitor of aldose reductase, an enzyme involved in the development of diabetic cataract. By inhibiting this enzyme, BYAKANGELICIN can help in the treatment and prevention of diabetic cataract, a common complication in patients with diabetes.

InChI:InChI=1/C17H18O7/c1-17(2,20)11(18)8-23-16-14-10(6-7-22-14)13(21-3)9-4-5-12(19)24-15(9)16/h4-7,11,18,20H,8H2,1-3H3

Downstream Products

• 35214-81-4 4-methoxy-9-(3-methyl-2-oxo-butoxy)-furo[3,2-g]chromen-7-one 
• 61046-59-1 (+/-)-byakangelicol 

Relevant articles and documents

Benzofuran and coumarin derivatives from the root of Angelica dahurica and their PPAR-γ ligand-binding activity

A phytochemical investigation of the root of Angelica dahurica led to the isolation of benzofuran and coumarin derivatives. This is the first report of the isolation and identification of three furanocoumarin sulfates from A. dahurica root. The structures of a total of twelve undescribed compounds were determined by extensive spectroscopic analysis, including 2D NMR data, hydrolysis, and solvolysis, followed by either physicochemical and spectroscopic data or X-ray crystallographic analysis. The isolated compounds were evaluated for their PPAR-γ ligand-binding activity, and six compounds showed significant PPAR-γ ligand-binding activity. In particular, the undescribed benzofuran derivative, 3-[6,7-furano-9-hydroxy-4-(2″,3″-dihydroxy-3″-methylbutyloxy)]-phenyl propionic acid, exhibited the most potent PPAR-γ ligand-binding activity and accumulated intracellular lipid in 3T3-L1 cells.