4829-02-1

Basic information

• Product Name: Cyclohexanone, 2-hydroxy-2-phenyl-
• Synonyms: 1-hydroxy-2-oxo-1-phenyl-cyclohexane;2-hydroxy-2-phenylcyclohexanone;2-Hydroxy-2-phenyl-cyclohexanon
• CAS NO: 4829-02-1
• Molecular Formula: C12H14O2
• Molecular Weight: 190.242
• Mol File: 4829-02-1.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: Cyclohexanone, 2-hydroxy-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 2-hydroxy-2-phenyl-(4829-02-1)
• EPA Substance Registry System: Cyclohexanone, 2-hydroxy-2-phenyl-(4829-02-1)

Safety Data

• Hazardous Substances Data: 4829-02-1(Hazardous Substances Data)

Upstream product

• 603126-64-3 2-phenyl-2-trimethylsilanyloxy-cyclohexanone 
• 41728-16-9 1,2-diphenylpropan-1,2-diol 
• 1041469-72-0 C₁₇H₂₈OSi₂ 
• 678975-43-4 2-phenyl-2-((phenylamino)oxy)cyclohexan-1-one 
• 1444-65-1 (RS)-2-phenylcyclohexanone 
• 100-47-0 benzonitrile 
• 5422-88-8 phenyl cyclopentyl ketone 
• 6740-66-5 (1-bromocyclopentyl)(phenyl)methanone 
• 19300-92-6 1-hydroxy-1-benzoylcyclopentane 
• 105873-83-4 (2S,3S,6S)-2,3-Bis-methoxymethyl-6-phenyl-1,4-dioxa-spiro[4.5]decan-6-ol 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 28353-03-9 6-oxo-6-phenylhexanenitrile 
• 771-98-2 1-Phenylcyclohexene 
• 1402927-17-6 ethyl 2-benzoyl-5-cyanopentanoate 

Downstream Products

• 4556-09-6 2-phenylcyclohex-2-enone 
• 65926-98-9 trans-1,2-Diphenylcyclohexane-1,2-diol 
• 27167-34-6 trans-1-Phenylcyclohexane-1,2-diol 
• 4912-60-1 2-phenyl-2-cyclohexen-1-one 2,4-dinitrophenylhydrazone 
• 790220-75-6 (trans)-1-methyl-2-phenylcyclohexane-1,2-diol 
• 15288-87-6 1-phenylheptane-1,6-dione 
• 3375-38-0 1,4-dibenzoylbutane 
• 72930-73-5 cis-1,2-Diphenylcyclohexane-1,2-diol 
• 7141-84-6 phenyl(1-(propylamino)cyclopentyl)methanone 
• 7015-53-4 2-phenyl-2-(propylamino)cyclohexanone 
• 1422515-64-7 (1-(hexylamino)cyclopentyl)(phenyl)methanone 
• 1422566-93-5 2-(hexylamino)-2-phenylcyclohexanone 
• 7062-16-0 (1-(isopropylamino)cyclopentyl)(phenyl)methanone 
• 7015-55-6 2-(isopropylamino)-2-phenylcyclohexanone 

Relevant articles and documents

Catalytic Asymmetric Acyloin Rearrangements of α-Ketols, α-Hydroxy Aldehydes, and α-Iminols by N, N′-Dioxide-Metal Complexes

A highly enantioselective acyloin rearrangement of cyclic α-ketols has been developed with a chiral Al(III)-N,N′-dioxide complex as catalyst. This strategy provided an array of optically active 2-acyl-2-hydroxy cyclohexanones in moderate to good yields with high enantioselectivities. The asymmetric isomerizations of acyclic α-hydroxy aldehydes and α-iminols were achieved as well under modified conditions, affording the corresponding chiral α-hydroxy ketones and α-amino ketones in moderate results. Moreover, further transformations of product to enantioenriched diols were carried out.

An Unexpected α-Oxidation of Cyclic Ketones with 1,4-Benzoquinone by Enol Catalysis

The first direct and asymmetric α-aryloxylation of cyclic ketones via enol catalysis has been achieved using quinones as the reaction partners. Catalytic amounts of a phosphoric acid promote the exclusive formation of α,α-disubstituted ketones from the corresponding α-substituted ketones in good yields and enantioselectivities (up to 96.5:3.5 er). Preliminary mechanistic experiments suggest that this reaction proceeds via a proton-coupled electron transfer (PCET) followed by radical recombination.

Iron(iii) chloride hexahydrate-promoted selective hydroxylation and chlorination of benzyl ketone derivatives for the construction of hetero-quaternary scaffolds

A novel and tunable α-hydroxylation/α-chlorination of benzyl ketone derivatives has been developed for the construction of hetero-quaternary carbon centers by iron(iii) chloride hexahydrate mediated selective transformations through the application of dif