4839-46-7 Usage
Description
3,3-Dimethylglutaric acid, also known as an alpha,omega-dicarboxylic acid, is a glutaric acid derivative with two methyl groups substituted at the C-3 position. It is a white to beige fine crystalline powder and is recognized for its versatile chemical properties.
Uses
Used in Pharmaceutical Industry:
3,3-Dimethylglutaric acid is used as a reactant for the synthesis of various pharmaceutical compounds, such as conjugates of betulin derivatives used as anti-HIV agents. It plays a crucial role in the development of new therapeutic agents to combat HIV.
Used in Chemical Synthesis:
3,3-Dimethylglutaric acid is used as a versatile reactant in the synthesis of various compounds, including dimeric peptide antagonists of IgG-FcRn interaction, which are essential in the study and treatment of immunological disorders.
Used in Organic Chemistry:
3,3-Dimethylglutaric acid is employed in cyclodehydration of diols, a key reaction in organic chemistry for the synthesis of various cyclic compounds with potential applications in different industries.
Used in Microwave-Assisted Chemistry:
3,3-Dimethylglutaric acid is used as a reactant in microwave-assisted protection of glutaraldehyde, a technique that enhances the efficiency and speed of chemical reactions, leading to improved synthesis processes.
Used in Proteasome Inhibition:
3,3-Dimethylglutaric acid is used as a reactant in the synthesis of glycyrrhetinic acid derivatives, which are known for their proteasome inhibition properties. These compounds have potential applications in the development of anti-cancer drugs.
Used in Asymmetric Transannular Aldolizations:
3,3-Dimethylglutaric acid is used as a reactant in catalytic, asymmetric transannular aldolizations, a significant reaction in organic chemistry for the synthesis of complex organic molecules with potential applications in various fields, including pharmaceuticals and materials science.
Used in Natural Product Synthesis:
3,3-Dimethylglutaric acid is a versatile reactant used in the synthesis of (+)-Hirsutene, a natural product with potential applications in the fragrance, flavor, and pharmaceutical industries.
Check Digit Verification of cas no
The CAS Registry Mumber 4839-46-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,3 and 9 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4839-46:
(6*4)+(5*8)+(4*3)+(3*9)+(2*4)+(1*6)=117
117 % 10 = 7
So 4839-46-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H12O4/c1-7(2,3-5(8)9)4-6(10)11/h3-4H2,1-2H3,(H,8,9)(H,10,11)/p-2
4839-46-7Relevant articles and documents
Haslam,J.L. et al.
, p. 1 - 6 (1965)
Reaction of epoxyketones with hydrogen peroxide - Ethane-1,1- dihydroperoxide as a surprisingly stable product
Hamann, Hans-Juergen,Bunge, Alexander,Liebscher, Juergen
scheme or table, p. 6849 - 6851 (2009/07/10)
Reaction of epoxyketones with hydrogen peroxide, ethane-1,1-dihydroperoxide as a stable product was reported. Triacetone triperoxide and methylhydroperoxide were reported as highly explosive compounds. Thermogravimetric investigations showed decomposition in the temperature range 60-130°C with the highest decomposition rate at about 105°C. Using differently substituted epoxyketones as reactants, it was able to isolate and characterize propane-1,1-dihydroperoxide. Epoxyketones can also be attacked by H2O2 at the carbonyl C atom and at both epoxy C atoms as electrophilic centers. Initial results revealed that the acid-catalyzed reaction of 5- and 7-ring homologues 1 (n=0,2) with H2O2 runs similarly. They also show a lower tendency to form the geminal dihydroperoxide.
Phase transfer catalysis by tetraethylammonium bromide: Nucleophilic opening of anhydrides using potassium superoxide in aprotic medium
Singh, Sundaram,Shukla, Ajay Kumar,Singh, Krishna Nand
, p. 1184 - 1188 (2007/10/03)
Tetraethylammonium superoxide, generated in situ by the phase transfer reaction of potassium superoxide and tetraethylammonium bromide, brings about a clean cleavage of various anhydrides, particularly those with high molecular weight in dry dimethylformamide. As an outcome, succinic anhydride 1; glutaric anhydride 2; 3,3-dimethylglutaric anhydride 3; phthalic anhydride 4; diphenic anhydride 5; 1,2,3,4-tetrahydro-9-oxo-1,4-ethanonaphthalene-2,3- endo-dicarboxylic anhydride 6: 1,4,5,6,7,7-hexachloro-5-norbomene-2,3- dicarboxylic anhydride 7; endo-bicyclo [2.2.1] heptan-2-one-5,6-dicarboxylic anhydride 8; cis-5-norbornene-endo-2,3-dicarboxylic anhydride 9 and trans- 1,2-cyclohexane dicarboxylic anhydride 10 have been transformed into their corresponding dicarboxylic acids in fairly good yields. The report demonstrates the applicability of tetraethylammonium bromide as a phase transfer catalyst for efficient superoxide studies.
