4850-50-4

Basic information

• Product Name: 1-phenylbutane-1,4-diol
• Synonyms: 1,4-butanediol, 1-phenyl-; 1-Phenylbutane-1,4-diol
• CAS NO: 4850-50-4
• Molecular Formula: C₁₀H₁₄O₂
• Molecular Weight: 166.217
• Mol File: 4850-50-4.mol
• Article Data: 66

Chemical Properties

• Boiling Point: 316.1°C at 760 mmHg
• Flash Point: 153.9°C
• Density: 1.1g/cm³
• Vapor Pressure: 0.000176mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: 1-phenylbutane-1,4-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenylbutane-1,4-diol(4850-50-4)
• EPA Substance Registry System: 1-phenylbutane-1,4-diol(4850-50-4)

Safety Data

• Hazardous Substances Data: 4850-50-4(Hazardous Substances Data)

Usage

General Description

1-Phenylbutane-1,4-diol is a chemical compound with the molecular formula C10H14O2. It is also known as 1,4-Dihydroxyphenylbutane and is a type of diol, containing two hydroxyl groups. 1-Phenylbutane-1,4-diol is used in the production of various industrial and consumer products such as cosmetics, pharmaceuticals, and lubricants. It is often used as a precursor in the synthesis of polymers and other compounds. 1-Phenylbutane-1,4-diol is a colorless, crystalline solid with a mild, sweet odor. It is considered to be relatively safe for use in these applications, however, as with all chemicals, proper handling and storage procedures should be followed to minimize risks to human health and the environment.

Upstream product

• 56139-59-4 4-oxo-4-phenyl-butyraldehyde 
• 25333-24-8 3-benzoylpropionic acid methyl ester 
• 2051-95-8 succinylbenzene 
• 6270-17-3 ethyl 3-benzoylpropanoate 
• 16939-57-4 (E)-buta-1,3-dienylbenzene 
• 1743-36-8 1-phenylbut-3-yn-1-ol 
• 112630-65-6 2-butoxy-3-chloro-1,2-oxaborinane 
• 100-58-3 phenylmagnesium bromide 
• 2146-67-0 (dichloromethyl)lithium 
• 112630-64-5 2-Phenyl-[1,2]oxaborolane 
• 109417-35-8 2,2-Dimethyl-6-phenyl-[1,2]oxasilinane 
• 90106-95-9 Bromomethyl-dimethyl-(1-phenyl-allyloxy)-silane 
• 100-52-7 benzaldehyde 
• 143878-46-0 1-phenyl-1-trimethylsilyloxy-4-t-butyldimethylsilyloxybutane 

Downstream Products

• 71052-93-2 1-phenyl-1,4-dibromobutane 
• 139313-42-1 1,4-diacetoxy-1-phenylbutane 
• 16133-83-8 tetrahydro-2-phenylfuran 
• 1008-76-0 4,5-dihydro-5-phenyl-2(3H)-furanone 
• 39755-03-8 4-hydroxy-1-phenyl-butan-1-one 
• 431-03-8 dimethylglyoxal 
• 121883-32-7 4-acetoxy-1-phenylbutan-1-ol 
• 137333-75-6 4-tert-butyldimethylsilyloxy-1-phenylbutan-1-ol 
• 139527-16-5 (S)-4-hydroxy-4-phenylbutyl acetate 
• 56139-59-4 4-oxo-4-phenyl-butyraldehyde 
• 219745-25-2 4-chloro-4-phenyl-1-butanol 
• 3360-41-6 4-phenyl-butan-1-ol 
• 111138-02-4 (-)-(S)-5-phenyl-4,5-dihydrofuran-2(3H)-one 
• 111138-03-5 (R)-4-phenylbutyrolactone 

Relevant articles and documents

Palladium-Catalyzed Enantioselective Carbene Insertion into Carbon-Silicon Bonds of Silacyclobutanes

We report herein a highly efficient palladium-catalyzed carbene insertion into strained Si-C bonds with excellent enantioselectivity, which provides a rapid and distinct method to access silacyclopentanes with a three- or four-substituted stereocenter asymmetrically. Mechanistic studies using hybrid density functional theory suggest a catalytic cycle involving oxidative addition, carbene migratory insertion, and reductive elimination. In addition, roles of the chiral ligands in controlling the reaction enantioselectivity are also elucidated.

Synthesis of Enantiopure γ-Lactones via a RuPHOX-Ru Catalyzed Asymmetric Hydrogenation of γ-Keto Acids

A RuPHOX?Ru catalyzed asymmetric hydrogenation of γ-keto acids has been developed, affording the corresponding enantiopure γ-lactones in high yields and with up to 97% ee. The reaction could be performed on a gram scale with a relatively low catalyst loading (up to 10000 S/C) under the indicated reaction conditions and the resulting products can be transformed to several enantiopure building blocks, biologically active compounds and enantiopure drugs. (Figure presented.).

Photo-organocatalytic synthesis of acetals from aldehydes

A mild and green photo-organocatalytic protocol for the highly efficient acetalization of aldehydes has been developed. Utilizing thioxanthenone as the photocatalyst and inexpensive household lamps as the light source, a variety of aromatic and aliphatic aldehydes have been converted into acyclic and cyclic acetals in high yields. The reaction mechanism was extensively studied.