485828-58-8

Basic information

• Product Name: 1-(4-Bromophenyl)cyclobutanecarbonitrile
• Synonyms: 1-(4-Bromophenyl)cyclobutanecarbonitrile;Cyclobutanecarbonitrile, 1-(4-bromophenyl)-;1-(4-bromophenyl)cyclobutanecarbonitrile - B9963
• CAS NO: 485828-58-8
• Molecular Formula: C₁₁H₁₀BrN
• Molecular Weight: 236.1078
• Mol File: 485828-58-8.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 336.236 °C at 760 mmHg
• Flash Point: 157.15 °C
• Appearance: /
• Density: 1.469 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: 1-(4-Bromophenyl)cyclobutanecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Bromophenyl)cyclobutanecarbonitrile(485828-58-8)
• EPA Substance Registry System: 1-(4-Bromophenyl)cyclobutanecarbonitrile(485828-58-8)

Safety Data

• Hazardous Substances Data: 485828-58-8(Hazardous Substances Data)

Usage

General Description

1-(4-Bromophenyl)cyclobutanecarbonitrile is a chemical compound with the molecular formula C11H9BrN. It is a yellow solid that is commonly used as a building block in organic synthesis, particularly in the pharmaceutical industry. 1-(4-Bromophenyl)cyclobutanecarbonitrile is a cyclobutanecarbonitrile derivative, with a bromine atom attached to the benzene ring. It has a wide range of applications, including as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and reactivity make it a valuable tool in the creation of complex organic molecules. However, it should be handled with care due to its potential toxicity and irritant properties.

InChI:InChI=1/C11H10BrN/c12-10-4-2-9(3-5-10)11(8-13)6-1-7-11/h2-5H,1,6-7H2

Upstream product

• 109-64-8 1,3-dibromo-propane 
• 16532-79-9 4-Bromophenylacetonitrile 

Downstream Products

• 1032350-05-2 1-(4-bromophenyl)cyclobutanecarboxylic acid amide 
• 1361189-40-3 1-[4-(2-aminopyrimidin-5-yl)phenyl]cyclobutanecarbonitrile 
• 1361186-35-7 5-(4-{1-[5-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl]cyclobutyl}-phenyl)-pyrimidin-2-ylamine 
• 1361188-44-4 5-(4-{1-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]-cyclobutyl}-phenyl)-pyridin-2-ylamine 
• 1361188-49-9 5-(4-{1-[5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]oxadiazol-3-yl]-cyclobutyl}-phenyl)pyrazin-2-ylamine 
• 1361189-45-8 1-(4-bromophenyl)-N-hydroxycyclobutanecarboxamidine 
• 1361189-54-9 3-[1-(4-bromo-phenyl)-cyclobutyl]-5-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-1,2,4-oxadiazole 
• 1361189-56-1 2-{3-[1-(4-bromophenyl)cyclobutyl]-[1,2,4]oxadiazol-5-yl}pyrazine 
• 1361189-57-2 {3-[1-(4-bromo-phenyl)-cyclobutyl]-1,2,4-oxadiazol-5-yl}-pyrrolidin-1-yl-methanone 
• 1361189-58-3 3-[1-(4-bromophenyl)cyclobutyl]-5-trichloromethyl-[1,2,4]oxadiazole 
• 1361189-59-4 3-[1-(4-bromo-phenyl)-cyclobutyl]-5-pyrrolidin-1-yl-1,2,4-oxadiazole 
• 1361189-60-7 3-[1-(4-bromo-phenyl)-cyclobutyl]-cyclopenta-1,3-dienecarboxylic acid dimethylamide 
• 1361189-79-8 3-[1-(4-bromo-phenyl)-cyclobutyl]-5-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]oxadiazole 
• 1361190-19-3 5-(1-methyl-1H-pyrazol-4-yl)-3-{1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclobutyl}-[1,2,4]oxadiazole 

Relevant articles and documents

Synthesis method of arylcyclobutane compound

The present invention discloses a method for synthesizing an arylcyclobutane compound to 1eq phenylacetonitrile and 1.1eq 1-bromo-3-chloropropane as raw material, N,N- dimethylacetamide as a solvent, plus 2.5eq sodium hydride, under the protection of iner

COMPOUNDS AND THEIR METHODS OF USE

The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.

Oxadiazole Amine Derivative Compounds as Histone Deacetylase 6 Inhibitor, and the Pharmaceutical Composition Comprising the same

The present invention relates to a novel compound having an activity of inhibiting histone deacetylase 6 (HDAC6), an optical isomer thereof or a pharmaceutically acceptable salt thereof, a use thereof for preparation of a drug for treatment, a pharmaceutical composition comprising the same, a treatment method using the composition, and a method for preparing the same. The novel compound, an optical isomer thereof or a pharmaceutically acceptable salt thereof according to the present invention has an activity of inhibiting histone deacetylase 6 (HDAC6), and is effective for preventing or treating HDAC6-related diseases, including infectious diseases; neoplasm; endocrine, nutritional and metabolic diseases; mental and behavior disorders; nerve disorders; eye and adnexa diseases; cardiovascular diseases; respiratory diseases; digestive organ diseases; skin and subcutaneous tissue diseases; musculoskeletal and connective tissue diseases; or congenital malformation, deformation and chromosomal abnormality.COPYRIGHT KIPO 2017