486394-58-5

Basic information

• Product Name: Carbamic acid, [[4-chloro-2-[[[[(2S)-1-[(2R)-3-cyclopropyl-2-hydroxy-3-methyl-1-oxobutyl ]-2-azetidinyl]carbonyl]amino]methyl]phenyl]methyl]-, 1,1-dimethylethyl ester
• CAS NO: 486394-58-5
• Molecular Formula: C25H36ClN3O5
• Molecular Weight: 494.031
• Mol File: 486394-58-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [[4-chloro-2-[[[[(2S)-1-[(2R)-3-cyclopropyl-2-hydroxy-3-methyl-1-oxobutyl ]-2-azetidinyl]carbonyl]amino]methyl]phenyl]methyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [[4-chloro-2-[[[[(2S)-1-[(2R)-3-cyclopropyl-2-hydroxy-3-methyl-1-oxobutyl ]-2-azetidinyl]carbonyl]amino]methyl]phenyl]methyl]-, 1,1-dimethylethyl ester(486394-58-5)
• EPA Substance Registry System: Carbamic acid, [[4-chloro-2-[[[[(2S)-1-[(2R)-3-cyclopropyl-2-hydroxy-3-methyl-1-oxobutyl ]-2-azetidinyl]carbonyl]amino]methyl]phenyl]methyl]-, 1,1-dimethylethyl ester(486394-58-5)

Safety Data

• Hazardous Substances Data: 486394-58-5(Hazardous Substances Data)

Upstream product

• 486394-56-3 methyl 2-hydroxy-3-cyclopropyl-3-methylbutanoate 
• 486394-55-2 methyl 3-cyclopropyl-3-methylbutanoate 
• 439116-15-1 2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamine 
• 439117-41-6 1-azidomethyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzene 
• 439117-40-5 tert-butyl 4-chloro-2-(hydroxymethyl)benzylcarbamate 
• 439117-38-1 methyl 5-chloro-2-cyanobenzoate 
• 63721-05-1 methyl 3,3-dimethyl-4-penteneoate 
• 27007-53-0 methyl-2-bromo-5-chlorobenzoate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 486394-57-4 (R)-3-Cyclopropyl-2-hydroxy-3-methyl-butyric acid 
• 439118-00-0 (2-{[(azetidine-2-carbonyl)-amino]-methyl}-4-chloro-benzyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Low molecular weight thrombin inhibitors with excellent potency, metabolic stability, and oral bioavailability

Modification of lead compound 1 by reducing lipophilicity in the P3 group produced a series of low molecular weight thrombin inhibitors with excellent potency in functional assays, metabolic stability, and oral bioavailability. These modifications led to