486994-14-3

Basic information

• Product Name: 4-formyl-2-iodo-6-methoxyphenyl acetate
• Synonyms: 4-formyl-2-iodo-6-methoxyphenyl acetate;(2-iodo-4-methanoyl-6-methoxy-phenyl) ethanoate;acetic acid (4-formyl-2-iodo-6-methoxyphenyl) ester;acetic acid (4-formyl-2-iodo-6-methoxy-phenyl) ester
• CAS NO: 486994-14-3
• Molecular Formula: C₁₀H₉IO₄
• Molecular Weight: 320.09
• Mol File: 486994-14-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-formyl-2-iodo-6-methoxyphenyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-formyl-2-iodo-6-methoxyphenyl acetate(486994-14-3)
• EPA Substance Registry System: 4-formyl-2-iodo-6-methoxyphenyl acetate(486994-14-3)

Safety Data

• Hazardous Substances Data: 486994-14-3(Hazardous Substances Data)

Upstream product

• 5438-36-8 5-iodovaniline 
• 75-36-5 acetyl chloride 
• 881-68-5 vanillin acetate 
• 121-33-5 vanillin 
• 108-24-7 acetic anhydride 

Downstream Products

• 98554-57-5 4-hydroxy-3-iodo-5-methoxy-benzoic acid 
• 194342-88-6 4-Acetoxy-3-iodo-5-methoxy-benzoic acid 
• 500117-74-8 [(trimethylsilyl)ethynyl]benzaldehyde 
• 670749-39-0 1-(3-methoxy-4-hydroxy-5-iodophenyl)-prop-2-en-1-ol 
• 245469-65-2 1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl]prop-2-en-1-one 
• 670749-40-3 1-(3-methoxy-4-hydroxy-5-iodophenyl)-prop-2-en-1-one 
• 670749-41-4 1-[4-(2-bromo-ethoxy)-3-iodo-5-methoxy-phenyl]-propenone 
• 670749-42-5 5-acryloyl-2-[2-(4-chloro-phenylsulfanyl)-ethoxy]-3-methoxy-benzonitrile 
• 265313-99-3 1-(3',4',5'-Trimethoxyphenyl)-4-[4'-(p-chlorophenylthioethyl)-oxy-5'-cyano-3'-methoxy]phenyl-1,4-dioxobutane 
• 339588-46-4 5-acetoxy-3-ethynyl-4-methoxybenzenemethanol 
• 500117-75-9 4-acetoxy-3-methoxy-5-[(trimethylsilyl)ethynyl]benzenemethanol 

Relevant articles and documents

TRPV-1 RECEPTOR ANTAGONIST COMPOUND DERIVED FROM 1,3,4-THIADIAZOLE ALKYLAMIDES AND CHALCONES

This technology encompasses compounds derived from 1, 3, 4-thiadiazole alkylamides and chalcone, which inhibit the activation of the TRPV-1 receptor using capsaicin and temperature. Also disclosed is the use of these compounds in the treatment of diseases with TRPV-1 overexpression, such as chronic pain.

Design and synthesis of conformationally restricted capsaicin analogues based in the 1, 3, 4-thiadiazoleheterocycle reveal a novel family of transient receptor potential vanilloid 1 (TRPV1) antagonists

4-hydroxy-3-methoxybenzaldehyde was used as starting material to obtain a number of 1, 3, 4-thiadiazole alkylamide derivatives. The pharmacological properties of these conformationally restricted capsaicin analogues were evaluated on HEK-293T cells transiently expressing TRPV1 receptor. By means of a highthroughput calcium imaging assay we find that 1, 3, 4-thiadiazoles (compounds 8-15) act as potent antagonists of the capsaicin receptor, inhibiting both, the capsaicin- and temperature-dependent activation. Docking studies suggested a different binding orientation on the vanilloid binding site when compared with capsaicin analogues, such as 5-iodononivamide. Overall, our studies suggest that 1, 3, 4-thiadiazoles interact with capsaicin 's binding region of the receptor, although using a different set of interactions within the vanilloid binding pocket.

BENZO(b)FURAN DIMERS

Benzo[b]furan dimers and processes for their preparation are provided. The invention provides a synthetic process for the preparation of benzo[b]furan dimer using mild reaction conditions, which provides a high substituent tolerance and is appropriate for