4878-36-8

Basic information

• Product Name: RARECHEM AL BO 1272
• Synonyms: RARECHEM AL BO 1272;3,5-DIAMINO-6-CHLOROPYRAZINE-2-CARBOXYLIC ACID;3,5-diamino-6-chloro-2-Pyrazinecarboxylic acid
• CAS NO: 4878-36-8
• Molecular Formula: C₅H₅ClN₄O₂
• Molecular Weight: 188.57
• Mol File: 4878-36-8.mol
• Article Data: 24

Chemical Properties

• Melting Point: 212-213 °C(Solv: acetone (67-64-1))
• Boiling Point: 480.5°C at 760 mmHg
• Flash Point: 244.4°C
• Appearance: /
• Density: 1.797g/cm³
• Vapor Pressure: 4.82E-10mmHg at 25°C
• Refractive Index: 1.749
• Storage Temp.: 2-8°C(protect from light)
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
• PKA: 3.94±0.10(Predicted)
• CAS DataBase Reference: RARECHEM AL BO 1272(CAS DataBase Reference)
• NIST Chemistry Reference: RARECHEM AL BO 1272(4878-36-8)
• EPA Substance Registry System: RARECHEM AL BO 1272(4878-36-8)

Safety Data

• Hazardous Substances Data: 4878-36-8(Hazardous Substances Data)

Usage

Description

RARECHEM AL BO 1272, also known as Glycerol, is a colorless, odorless, viscous liquid that is widely used in various industries due to its unique properties. It is a simple polyol compound and a sugar alcohol with three hydroxyl groups. Glycerol is hygroscopic, which means it can absorb water from the air, and it is also a humectant, helping to retain moisture in various applications.

Uses

Used in Pharmaceutical Industry:
RARECHEM AL BO 1272 is used as a solvent for various pharmaceutical applications, including the formulation of elixirs, syrups, and liquid medications. Its ability to dissolve a wide range of substances, including drugs, makes it an ideal choice for this purpose. Additionally, glycerol is used as a humectant to prevent the crystallization of drugs and maintain their stability.
Used in Cosmetics and Personal Care Industry:
In the cosmetics and personal care industry, RARECHEM AL BO 1272 is used as a humectant to help retain moisture in skin and hair care products, such as lotions, creams, and shampoos. Its ability to absorb water helps to keep the skin and hair hydrated and maintain their natural moisture balance.
Used in Food and Beverage Industry:
RARECHEM AL BO 1272 is used in the food and beverage industry as a humectant, preservative, and sweetener. It helps to retain moisture in baked goods, confections, and icing, preventing them from becoming too dry or hard. Glycerol is also used in the production of e-liquids for electronic cigarettes, providing a smooth and pleasant vaping experience.
Used in Industrial Applications:
In industrial applications, RARECHEM AL BO 1272 is used as a raw material in the production of various chemicals, such as glycerol esters, polyglycerols, and glycerol ethers. It is also used as a component in the manufacturing of explosives, due to its ability to act as an oxygen carrier.
Used in Research and Development:
RARECHEM AL BO 1272 is used in the study of insulin secretion in relation to amiloride, as well as in the development of β-blockers and diuretics. It is also utilized in the determination of impurities in pharmaceuticals, contributing to the quality control and safety of medications.

InChI:InChI=1/C5H5ClN4O2/c6-2-4(8)10-3(7)1(9-2)5(11)12/h(H,11,12)(H4,7,8,10)

Upstream product

• 1458-01-1 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid methyl ester 
• 2609-46-3 amiloride 

Downstream Products

• 25658-64-4 3,5-Diamino-6-chloro-pyrazinecarboxylic N,N-diphenylcarbamic anhydride 
• 345301-71-5 C₁₃H₁₄ClN₇OS 
• 345300-33-6 C₁₃H₁₃ClFN₇OS 
• 33249-57-9 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid N'-benzylidene-N-methyl-hydrazide 
• 1196038-89-7 ((S)-5-benzyloxycarbonylamino-1-{[(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-amino]-methyl}-pentyl)-carbamic acid tert-butyl ester 
• 1373437-54-7 C₁₉H₂₅ClN₆O₃ 
• 1431938-22-5 3,5-diamino-N-[(1E)-amino({4-[4-(2,3-dihydroxypropoxy)phenyl]butyl}amino)methylidene]-6-chloropyrazine-2-carboxamide 
• 2898-76-2 benzamil 
• 1432292-33-5 C₂₇H₃₈ClN₉O₄ 
• 1432293-11-2 C₂₆H₃₇ClN₁₀O₂ 
• 1432293-21-4 N-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-N’-(4-phenethyl-piperidin-4-yl)methylguanidine 
• 1432293-74-7 4-[N'-(3,5-diamino-6-chloropyrazine-2-carbonyl)guanidinomethyl]-4-phenethylpiperidine-1-carboxamidine 
• 1432293-97-4 C₄₆H₆₂Cl₂N₁₈O₄ 
• 1432294-01-3 N-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-N'-(4-phenethyl-1-phenylacetyl-piperidin-4-ylmethyl)-guanidine 

Relevant articles and documents

TETRA- AND PENTASUBSTITUTED BENZIMIDAZOLIUM COMPOUNDS USEFUL IN THE TREATMENT OF RESPIRATORY DISEASES

The present invention relates to compounds of formula (I), or the tautomers or pharmacologically acceptable acid addition salts thereof, wherein R1, R2, R3, R4, X, and Z have one of the meanings as defined in the specification, to the use of compounds of formula (I) as a medicament, to pharmaceutical composition comprising at least one com? pound of formula (I), as well as to medicament combinations containing one or more compounds of formula (I).

HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING THEM, USE AND PROCESSES FOR THE PREPARATION THEREOF

The present invention relates to compounds of general formula (I) and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, and the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.

NOVEL BENZIMIDAZOLIUM COMPOUNDS

The present invention relates to compounds of general formula (I) and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.