4887-91-6

Basic information

• Product Name: 1H-Benzimidazole,5-chloro-2-propyl-(9CI)
• Synonyms: 1H-Benzimidazole,5-chloro-2-propyl-(9CI);6-Chloro-2-propyl-1H-benzo[d]iMidazole;1H-BenziMidazole,6-chloro-2-propyl-;6-Chloro-2-propyl-1H-benzimidazole
• CAS NO: 4887-91-6
• Molecular Formula: C10H11ClN2
• Molecular Weight: 194.66074
• Product Categories: BENZIMIDAZOLE
• Mol File: 4887-91-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1H-Benzimidazole,5-chloro-2-propyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole,5-chloro-2-propyl-(9CI)(4887-91-6)
• EPA Substance Registry System: 1H-Benzimidazole,5-chloro-2-propyl-(9CI)(4887-91-6)

Safety Data

• Hazardous Substances Data: 4887-91-6(Hazardous Substances Data)

Usage

General Description

1H-Benzimidazole, 5-chloro-2-propyl-(9CI) is a chemical compound that belongs to the benzimidazole class of compounds. It is characterized by the presence of a benzene ring fused to an imidazole ring, which contains a chlorine atom and a propyl group attached to the nitrogen atom at position 2. 1H-Benzimidazole,5-chloro-2-propyl-(9CI) has a variety of potential applications in the field of organic chemistry and pharmaceuticals due to its structural features, which give it the potential to interact with biological systems and exhibit various biological activities. It may be utilized as a building block for the synthesis of other chemical compounds or as a starting material for the development of new pharmaceutical agents with targeted effects on specific biological processes. Additionally, it may also have other industrial or research applications where its unique chemical structure can be harnessed for specific purposes.

Upstream product

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Relevant articles and documents

Oxone-mediated annulation of 2-aminobenzamides and 1,2-diaminobenzenes with: Sec -amines via imine- N -oxides: New syntheses of 2,3-dihydroquinazolin-4(1 H)-ones and 1 H -benzimidazoles

An efficient and mild method for the preparation of 2,3-dihydroquinazolin-4(1H)-ones and 1H-benzimidazoles by the oxone-mediated reaction of sec-amines via imine-N-oxides with 2-amino-N-substituted benzamides and 1,2-diaminobenzenes respectively in THF-wa

A general approach to substituted benzimidazoles and benzoxazoles via heterogeneous palladium-catalyzed hydrogen-transfer with primary amines

The synthesis of benzimidazoles starting from o-phenylenediamines and amines in the presence of palladium on charcoal as catalyst is reported. Under microwave dielectric heating it is possible to use a tertiary, a secondary, and even a primary amine as the substrate for a palladium-mediated process to get 2-substituted or 1,2-disubstituted benzimidazoles, depending on the nature of the o-phenylenediamine employed. Primary amines are the most suitable reagents for the atom economy of the overall process that resulted to be general as several different substituted benzimidazoles were obtained in good yield. Benzoxazoles can be also prepared starting from primary amines and o-aminophenol. The reaction is also highly selective as no (poly)-alkylated phenylenediamines or cross-contaminated benzimidazoles are obtained starting from N-monoalkylphenylenediamines. This behavior was interpreted as a scarce aptitude to dehydrogenation of the methylene bonded to the aromatic NH of N-alkylarylamines. The experiments carried out consent to draw an almost complete picture of the reaction pathways occurring during the process. The catalyst can be recycled several times and, although far from optimal performances, catalyst TON=90 is encouraging for further large-scale optimization protocols. In addition, the palladium on charcoal-catalyzed microwave-assisted reaction of o-phenylenediamine gives de-alkylation of tertiary amines and transformation into the secondary ones. Copyright

An easy one-step photocatalytic synthesis of 1-aryl-2-alkylbenzimidazoles by platinum loaded TiO2 nanoparticles under UV and solar light

One-pot synthesis of disubstituted benzimidazoles from N-substituted 2-nitroanilines or 1,2-diamines with 3-12 nm-sized platinum particles loaded on the TiO2 using solar and UV-A light is described. 1-Aryl-2-alkylbenzimidazoles from 2-nitrodiphenylamines are formed by combined redox photocatalytic reaction, condensation and catalytic dehydrogenation on Pt-TiO2. In case of diamines, this reaction is proceeded by Pt-TiO2 assisted photocatalytic oxidation of an alcohol and a catalytic dehydrogenation of the intermediate on the surface of platinum nanoparticles. In both cases product formation was achieved by tandem photocatalytic and catalytic reactions on Pt-TiO2.