488786-75-0

Basic information

• Product Name: 2-(3,4-dimethylphenyl)-2-oxoethyl 4-(3,5-dioxo-4-azatricyclo[5.2.1.0~2,6~]dec-8-en-4-yl)benzoate
• Synonyms: 2-(3,4-dimethylphenyl)-2-oxoethyl 4-(3,5-dioxo-4-azatricyclo[5.2.1.0~2,6~]dec-8-en-4-yl)benzoate
• CAS NO: 488786-75-0
• Molecular Formula: C26H23NO5
• Molecular Weight: 429.46452
• Mol File: 488786-75-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(3,4-dimethylphenyl)-2-oxoethyl 4-(3,5-dioxo-4-azatricyclo[5.2.1.0~2,6~]dec-8-en-4-yl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-dimethylphenyl)-2-oxoethyl 4-(3,5-dioxo-4-azatricyclo[5.2.1.0~2,6~]dec-8-en-4-yl)benzoate(488786-75-0)
• EPA Substance Registry System: 2-(3,4-dimethylphenyl)-2-oxoethyl 4-(3,5-dioxo-4-azatricyclo[5.2.1.0~2,6~]dec-8-en-4-yl)benzoate(488786-75-0)

Safety Data

• Hazardous Substances Data: 488786-75-0(Hazardous Substances Data)

Upstream product

• 2633-50-3 2-bromo-1-(3,4-dimethylphenyl)ethanone 
• 555-06-6 sodium p-aminobenzoate 
• 855124-46-8 4-amino-benzoic acid 2-(3,4-dimethyl-phenyl)-2-oxo-ethyl ester 
• 129-64-6 cis-5-norbornene-exo-2,3-dicarboxylic anhydride 

Relevant articles and documents

Non-competitive inhibitors of metabotropic glutamate receptor 5 (mGluR5)

Based on a pharmacophore alignment on known non-competitive mGluR5 inhibitors applying 4SCan technology, a new lead series was identified and further structurally investigated. Ki's as low as around 100 nM were achieved.