4891-79-6Relevant articles and documents
Heteropoly acid catalyzed cyclization of nerolidol and farnesol: Synthesis of α-bisabolol
De Meireles, Augusto L.P.,Costa, Maíra Dos Santos,Da Silva Rocha, Kelly A.,Gusevskaya, Elena V.
, p. 271 - 275 (2015/07/07)
Heteropoly acid H3PW12O40 is an active and environmentally friendly homogeneous catalyst for the synthesis of α-bisabolol, a high-priced and highly demanded ingredient for the fragrance, cosmetic and pharmaceutical industries, starting from more abundant biomass-based sesquiterpenic alcohols. The solvent nature remarkably affects the reaction pathways and product selectivity. In acetone solutions, α-bisabolol can be obtained in 55-60% GC yields from nerolidol and 60-70% GC yields from farnesol at complete substrate conversions, which are probably the best results ever reported for these reactions. α-Bisabolol synthesized by this method contains no farnesol, which is a potentially allergenic compound and should be avoided in the commercially used α-bisabolol. This advantage is especially important because the distillative separation of α-bisabolol and farnesol is a troublesome task. The catalyst shows high turnover numbers and operates under mild nearly ambient conditions.
CYCLIZATION OF SOME LINEAR TERPENOLS INITIATED BY "ACTIVATED" DMSO
Surkova, A. A.,Lozanova, A. V.,Dragan, V. A.,Gur'yan, V. A.,Moiseenkov, A. M.
, p. 760 - 762 (2007/10/02)
It was shown that the acylhydroxysulfonium salt generated in situ from DMSO and trifluoroacetic anhydride causes low-temperature cyclization of geraniol, linalool, and nerol in an aprotic medium to a mixture of p-menthane monoterpenoids, and the maximum yield is obtained in the case of the last two terpenols.A similar result was obtained for E-nerolidol.
AN ELECTROCHEMICAL METHOD SPECIFICALLY DIRECTED TO THE PREPARATION OF DL-BISABOLOL FROM DL-NEROLIDOL
Uneyama, Kenji,Masatsugu, Yosinori,Ueda, Takesi,Torii, Sigeru
, p. 529 - 530 (2007/10/02)
A product-selective electrosynthesis of dl-bisabolol from dl-nerolidol was accomplished by a constant current electrolysis in commercial acetone containing a small amount of LiClO4