4894-61-5Relevant articles and documents
Young et al.
, p. 1076,1080 (1951)
N - (4 - alkyl - 5 - benzyl thiazole - 2 - yl) amide and its preparation method and application
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Paragraph 0020; 0021, (2017/08/25)
The invention relates to N-(4-alkyl-5-benzyl thiazole-2-base) enoyl-amine or salt thereof, shown as a chemical structure formula I, wherein in the formula I, R is selected from C1-C2 alkyl, C3-C4 straight chains or C3-C4 branched alkyl; Y1 and Y3 are selected from hydrogen, methyl, ethyl, hydroxyl, methoxyl, ethoxyl, fluorine, chlorine, bromine or iodine; Y2 and Y4 are selected from hydrogen, methyl and ethyl; n is selected from 1,2,3,4,5,6 or 7; z is selected from hydrogen, methyl or phenyl; salt is selected from hydrochloride, hydrobromide, sulphate, phosphate, mesylate, benzene sulfonate and itramine tosylate. The invention provides the application of the N-(4-alkyl-5-benzyl thiazole-2-base) enoyl-amine or the salt thereof in preparation of anticancer drugs.
α-Selective Allylation of Isatin Imines Using Metallic Barium
Yanagisawa, Akira,Yamafuji, Seiya,Sawae, Toshiki
supporting information, p. 2019 - 2023 (2016/08/09)
The Barbier-type allylation of isatin imines with allylic chlorides was achieved by using metallic barium as the promoter. Various α-allylated 3-amino-2-oxindoles were synthesized from the corresponding allylic chlorides and isatin imines. The double-bond geometry of allylic chlorides was retained throughout the reaction. An arylic bromide or iodide functionality of the products was robust to metalation under the optimum reaction conditions.