491-78-1 Usage
Description
5-HYDROXYFLAVONE is a flavone derivative known for its diverse applications in various fields, including pharmaceuticals, materials science, and chemical research. It is characterized by its unique chemical structure, which allows it to participate in various reactions and exhibit different properties.
Uses
Used in Pharmaceutical Applications:
5-HYDROXYFLAVONE is used as a reactant for the synthesis of copper(II) complexes, which serve as bioactive molecules to combat antioxidants. These complexes have potential applications in the development of novel drugs and therapies.
5-HYDROXYFLAVONE is also used in thermal behavior studies of vanadyl complexes with flavone derivatives, which are considered as insulin-mimetic agents. This application is significant for the development of treatments for diabetes and related metabolic disorders.
Used in Chemical Research:
In the field of chemical research, 5-HYDROXYFLAVONE is used as a reactant in O-methylation reactions with di-Me carbonate. This process allows for the modification of the molecule's properties, which can be useful in the synthesis of new compounds with specific applications.
Furthermore, 5-HYDROXYFLAVONE is utilized in Density Functional Theory (DFT) studies on excited-state intramolecular proton transfer. These studies contribute to the understanding of the molecule's behavior and can lead to the development of new materials with unique properties.
Check Digit Verification of cas no
The CAS Registry Mumber 491-78-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,9 and 1 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 491-78:
(5*4)+(4*9)+(3*1)+(2*7)+(1*8)=81
81 % 10 = 1
So 491-78-1 is a valid CAS Registry Number.
InChI:InChI=1/C15H10O3/c16-11-7-4-8-13-15(11)12(17)9-14(18-13)10-5-2-1-3-6-10/h1-9,16H
491-78-1Relevant articles and documents
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Tyukavkina,Pogodaeva
, (1972)
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An Efficient One-Pot Synthesis and Anticancer Activity of 4'-Substituted Flavonoids
Wang,Liu,Zhang
, p. 1036 - 1041 (2018/07/06)
A number of 4'-substituted (R = H, Me, Cl, F) flavone derivatives is synthesized from 2-hydroxyacetophenones using the modified Baker–Venkataraman reaction. Compound [3-(4-fluorobenzoyl)-5- hydroxy-4'-fluoroflavone] was synthesized for the first time with the yield of 12%. Antiproliferative assays indicate that the synthesized flavones with F substituent at the 4' position demonstrate higher activity than the other flavone derivatives, particularly against HeLa and MCF-7 with the IC50 9.5 and 2.7 μM, respectively.
2-substituted benzopyran-4-one compounds and application thereof
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Paragraph 0178; 0179; 0180, (2016/10/08)
The invention relates to the technical field of medicine and discloses 2-substituted benzopyran-4-one compounds with a structure shown in general formula I and an application of the compounds in preparation of antifungal drugs and synergistic antifungal drugs. The compounds can be jointly used with azole antifungal drugs, can improve sensibility of drug-resistance bacteria to the azole drugs, reverses drug resistance and produces a synergistic antifungal function.
