4915-22-4Relevant articles and documents
Synthesis method of furan acetate compound
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Paragraph 0014-0015; 0020, (2021/06/06)
The invention discloses a synthesis method of a furan acetate compound, wherein the synthesis method comprises the steps: by taking a furfuryl alcohol compound as a raw material, carbon monoxide gas as a carbonyl source and an ester compound as an additive, carrying out carbonylation reaction in an organic solvent under the action of a catalyst to obtain the furan acetate compound, wherein the catalyst is a combination of alkali, palladium metal salt and a phosphine-containing ligand. The furfuryl alcohol compound is used as the raw material, the furan acetate compound is synthesized by increasing the carbon number of the furfuryl alcohol compound through carbonylation, the synthesis process is simple, the synthesis condition is mild, the cost is low, the yield of furfuryl acetate is high, and meanwhile conversion and utilization of renewable resource biomass furfuryl alcohol are achieved.
Anti-Markovnikov Hydroheteroarylation of Unactivated Alkenes with Indoles, Pyrroles, Benzofurans, and Furans Catalyzed by a Nickel-N-Heterocyclic Carbene System
Schramm, York,Takeuchi, Makoto,Semba, Kazuhiko,Nakao, Yoshiaki,Hartwig, John F.
supporting information, p. 12215 - 12218 (2015/10/12)
We report the catalytic addition of C-H bonds at the C2 position of heteroarenes, including pyrroles, indoles, benzofurans, and furans, to unactivated terminal and internal alkenes. The reaction is catalyzed by a combination of Ni(COD)2 and a sterically hindered, electron-rich N-heterocyclic carbene ligand or its analogous Ni(NHC)(arene) complex. The reaction is highly selective for anti-Markovnikov addition to α-olefins, as well as for the formation of linear alkylheteroarenes from internal alkenes. The reaction occurs with substrates containing ketones, esters, amides, boronate esters, silyl ethers, sulfonamides, acetals, and free amines.
Regioselective synthesis of functionalized furans by cyclization of 1,3-bis-silyl enol ethers with 1-chloro-2,2-dimethoxyethane
Bellur, Esen,Goerls, Helmar,Langer, Peter
, p. 2074 - 2090 (2007/10/03)
Cyclization of 1,3-bis-silyl enol ethers with 1-chloro-2,2-dimethoxyethane allowed an efficient, regio- and diastereo-selective synthesis of a variety of 2-alkylidene-4-methoxy-tetrahydrofurans. The TFA-mediated elimination of methanol resulted in the formation of functionalized furans. Simi larly, 2,3,3a,4,5,6-hexahydro-2,3-benzofurans were prepared and transformed into 4,5,6,7-tetrahydro-2,3-benzofurans by treatment with TFA Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.