492446-30-7

Basic information

• Product Name: C₁₉H₂₀N₂O₄S
• Synonyms: C₁₉H₂₀N₂O₄S
• CAS NO: 492446-30-7
• Molecular Weight: 372.445
• Mol File: 492446-30-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₀N₂O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₀N₂O₄S(492446-30-7)
• EPA Substance Registry System: C₁₉H₂₀N₂O₄S(492446-30-7)

Safety Data

• Hazardous Substances Data: 492446-30-7(Hazardous Substances Data)

Upstream product

• 15781-74-5 bis(2,4,6-trichlorophenyl)-2-benzylmalonate 
• 492446-25-0 (2,2-dimethyl[1,3]dioxolan-4-ylmethyl)thiazol-2-ylamine 
• 22195-47-7 4-aminomethyl-2,2-dimethyl[1,3]dioxolane 

Relevant articles and documents

The synthesis and properties of new carbohydrate-modified mesoionic thiazolo[3,2-a]pyrimidine-5,7-dione acyclonucleosides

The synthesis of the first examples of Class II mesoionic thiazolopyrimidine acyclonucleosides (MTA) incorporating the 2,3-dihydroxypropyl moiety as the sugar simulator is described. First, 2-bromothiazole was reacted with excess 1-amino-2,3-propanediol acetonide via an aromatic nucleophilic substitution reaction to yield 1-(2-thiazolylamino)-2,3-propanediol acetonide. This acetonide intermediate was condensed at 160° with substituted bis(2,4,6-trichlorophenyl) malonic esters to form a series of protected acyclonucleosides termed anhydro-(8-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-5-hydroxy-7- oxothiazolo[3,2-a]pyrimidinium hydroxides) which differ in their 6-position substituent. Deprotection of these acyclonucleosides using p-toluenesulfonic acid catalyst in methanol at 65° yielded the desired Class II MTA, anhydro-(8-(2,3dihydroxypropyl)-5-hydroxy-7-oxothiazolo[3,2-a]pyrimidinium hydroxides).