4940-56-1Relevant articles and documents
Design and synthesis of a novel “turn-on” fluorescent probe based on benzofuran-3(2H)-one for detection of hydrazine in water samples and biological systems
Guo, Meng-Ya,Jiang, Ai-Qin,Jiang, Cheng-Yan,Jiao, Qing-Cai,Wang, Kai,Yang, Yu-Shun,Ye, Ya-Xi,Zhang, Xiang-Yang,Zhu, Hai-Liang
, (2021)
Hydrazine is a very important industrial chemical with high toxicity to the human body. In this work, a fluorescent probe HZ, based on the substitution-cyclization-elimination cascade which initiated by hydrazine, was designed and synthesized. HZ had various characteristics such as high selectivity, high sensitivity, fast detection speed, wide application range, and so on. After treating with hydrazine, the fluorescence signal of HZ at 520 nm in aqueous solution was significantly enhanced. Furthermore, HZ had the linear range of 1–10 equivalent for monitoring hydrazine, and the solution showed a colorless to yellow color change. In practical application, the detection limit of HZ for the detection of hydrazine was only 0.75 μM, which could be utilized for trace detection of hydrazine in different water samples. These indicated that HZ had a broad application prospect in the fields of environmental protection and water treatment. This work not only provided a useful instrument for the detection of the ecological environment but also supplied important information for the system optimization of other ecological environment detectors. In addition, HZ could monitor endogenous and exogenous hydrazine in MCF-7 cells successfully, which demonstrated its potential for practical application in complex biological systems.
Synthesis of 6-hydroxyaurone analogues and evaluation of their α-glucosidase inhibitory and glucose consumption-promoting activity: Development of highly active 5,6-disubstituted derivatives
Sun, Hua,Ding, Weina,Song, Xiaotong,Wang, Dong,Chen, Mingzhu,Wang, Kaili,Zhang, Yazhou,Yuan, Peng,Ma, Ying,Wang, Runling,Dodd, Robert H.,Zhang, Yongmin,Lu, Kui,Yu, Peng
, p. 3226 - 3230 (2017/07/07)
A series of 6-hydroxyaurones and their analogues have been synthesized and evaluated for their in vitro α-glucosidase inhibitory and glucose consumption-promoting activity. These compounds exhibited varying degrees of α-glucosidase inhibitory activity, 11 of them showing higher potency than that of the control standard acarbose (IC50?=?50.30?μM). Surprisingly, analogues devoid of a substituent at C-2 but having an aryl group at C-5 were found to be highly active (e.g., 7f, IC50?=?9.88?μM). Docking analysis substantiated these findings. The kinetic analysis of compound 7f, the most potent α-glucosidase inhibitor of this study, revealed that it inhibited α-glucosidase in an irreversible and mixed competitive mode. In addition, compounds 7f and 10c exhibited significant glucose consumption promoting activity at 1?μM.
Synthesis and antiproliferative activity of 2-arylidene 6-(2-aryl-2-oxoethoxy)benzofuran-3-one derivatives
Demirayak, Seref,Yurttas, Leyla,Karaburun, Ahmet Cagri,Gundogdu-Karaburun, Nalan,Kayagil, Ismail
, p. 563 - 569 (2016/07/19)
The synthesis of 2-arylidene 6-(2-aryl-2-oxoethoxy)benzofuran-3-one derivatives was reported and selected compounds were determined for their anticancer activity evaluation in National Cancer Institute NCI, USA according to the drug screening protocol of the institute against approximately 60 tumor cell lines derived from nine cancer diseases. Compound 3r, namely 2-(4-chlorobenzylidene)-6-[2-(4-methoxyphenyl)-2-oxoethoxy]benzofuran-3-one exhibited the highest antitumor activity against non-small lung cancer cell lines.
