4943-83-3

Basic information

• Product Name: 2-AMINO-N-(2-PROPYNYL)BENZENECARBOXAMIDE
• Synonyms: 2-AMINO-N-(2-PROPYNYL)BENZENECARBOXAMIDE
• CAS NO: 4943-83-3
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.2
• Mol File: 4943-83-3.mol
• Article Data: 25

Chemical Properties

• Melting Point: 100-101°C
• Boiling Point: 378.5°Cat760mmHg
• Flash Point: 182.7°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 6.27E-06mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 2-AMINO-N-(2-PROPYNYL)BENZENECARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-N-(2-PROPYNYL)BENZENECARBOXAMIDE(4943-83-3)
• EPA Substance Registry System: 2-AMINO-N-(2-PROPYNYL)BENZENECARBOXAMIDE(4943-83-3)

Safety Data

• Statements: 43
• Safety Statements: 36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 4943-83-3(Hazardous Substances Data)

Usage

General Description

2-AMINO-N-(2-PROPYNYL)BENZENECARBOXAMIDE is a chemical compound with the molecular formula C11H13N3O. It is a benzene derivative with an amide functional group and a propynyl substituent. This chemical is a pale yellow solid with a molecular weight of 191.24 g/mol. It is used in various pharmaceutical and research applications, including as a building block in the synthesis of new organic compounds and as a starting material for the production of pharmaceutical drugs. Additionally, it has potential uses in the development of new materials and in biomedical research.

InChI:InChI=1/C10H10N2O/c1-2-7-12-10(13)8-5-3-4-6-9(8)11/h1,3-6H,7,11H2,(H,12,13)

Upstream product

• 118-48-9 isatoic anhydride 
• 2450-71-7 Propargylamine 
• 1246999-28-9 2-(4-hydroxy-phenylazo)-N-(prop-2-ynyl)benzamide 
• 53007-15-1 2-nitro-N-(prop-2-ynyl)benzamide 
• 118-92-3 anthranilic acid 
• 5344-90-1 2-Aminobenzyl alcohol 

Downstream Products

• 16347-56-1 3-(prop-2-yn-1-yl)quinazolin-4(3H)-one 
• 52829-71-7 2-(2-aminophenyl)-5-methyloxazole 
• 823235-08-1 acetic acid (2-prop-2-ynylcarbamoylphenylcarbamoyl)methyl ester 
• 1022946-99-1 2-[5-chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-ylamino)-pyrimidin-4-ylamino]-N-prop-2-ynyl-benzamide 
• 1022946-98-0 2-(2,5-dichloro-pyrimidin-4-ylamino)-N-prop-2-ynyl-benzamide 
• 1374606-56-0 9-(2-(4-((2-aminobenzamido)methyl)-1H-1,2,3-triazol-1-yl)ethylamino-N-(2-dimethylamino)ethyl)acridine-3-carboxamide 
• 1384487-71-1 16a-phenyl-16,16a-dihydrobenzo[5,6][1,2,3]triazolo[5',1':3,4][1,4]diazepino[7,1-b]quinazolin-11(9H)-one 
• 1384487-72-2 C₂₃H₁₆ClN₅O 
• 126554-92-5 2-(4,5-dihydro-5-methyleneoxazol-2-yl)benzenamine 

Relevant articles and documents

Effects Of 2-Methyl-3-propynylquinazolin-4-(3H)-one On Vascular Reactivity in Isolated Porcine Tail Arteries

The vascular effects of 2-methyl-3-propynylquinazolin-4-(3H)-one (QUIN) have been studied on isolated porcine tail arteries. QUIN had no effect on resting tension but relaxed, dose-dependently, arteries precontracted with noradrenaline or high-K+/su

Synthesis of Novel Isoindolo[2,1-a]quinazolinedione Derivatives Containing a 1,2,3-Triazole Ring System

A synthesis of isoindolo[2,1-a]quinazolinedione derivatives, coupled with a 1,2,3-triazole ring system, via the reaction of isatoic anhydride, HC=CCH2NH2, and 2-formylbenzoic acid is described, which led to the formation of the isoin

Quinazolinone [2, 3 - a] carboline derivative as well as preparation method and application thereof

The main content of the invention is to provide a new quinazolinone [2, 3 - a] carboline compound as well as a preparation method and application thereof, and has the quinazolinone of the general formula (I) and [2, 3 - a] carboline compounds. A quinazolo

Glycosyl triazoles as novel insect β-N-acetylhexosaminidase OfHex1 inhibitors: Design, synthesis, molecular docking and MD simulations

The insect enzyme GH20 β-N-acetyl-D-hexosaminidase OfHex1 represents an important chitinolytic enzyme found in the agricultural pest Ostrinia furnacalis (Guenée) and inhibition of this enzyme has been considered a promising strategy for the development of eco-friendly pesticides. In this article, based on the structure of the catalytic domains of OfHex1, a series of novel glycosyl triazoles were designed and synthesized via Cu-catalyzed azide-alkyne [3+2] cycloaddition reaction. To investigate the potency and selectivity of these glycosyl triazoles, the inhibition activities towards OfHex1 and HsHexB (human β-N-acetylhexosaminidase B) were studied. Particularly compound 17c (OfHex1, Ki = 28.68 μM; HsHexB, Ki > 100 μM) exhibited a suitable activity and selectivity against OfHex1. Furthermore, the possible inhibitory mechanisms of 17c with OfHex1 were studied using molecular docking and MD simulations. The structure-activity relationship results as well as the formed binding patterns may provide promising insights into the further development of novel OfHex1 inhibitors.