49601-28-7

Basic information

• Product Name: 1H-Pyrrole-2,5-dione, 3-(methylthio)-4-phenyl-, 2-oxime
• CAS NO: 49601-28-7
• Molecular Formula: C11H10N2O2S
• Molecular Weight: 234.279
• Mol File: 49601-28-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-2,5-dione, 3-(methylthio)-4-phenyl-, 2-oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2,5-dione, 3-(methylthio)-4-phenyl-, 2-oxime(49601-28-7)
• EPA Substance Registry System: 1H-Pyrrole-2,5-dione, 3-(methylthio)-4-phenyl-, 2-oxime(49601-28-7)

Safety Data

• Hazardous Substances Data: 49601-28-7(Hazardous Substances Data)

Upstream product

• 140-29-4 phenylacetonitrile 

Downstream Products

• 398130-26-2 1-methyl-3-methylsulfanyl-4-phenyl-pyrrole-2,5-dione 
• 86-34-0 phensuximide 
• 22903-00-0 3-(methylthio)-4-phenyl-1H-pyrrole-2,5-dione 
• 3464-18-4 3-phenylpyrrolidine-2,5-dione 

Relevant articles and documents

Synthesis of 3-methylthio-4-aryl-3-pyrroline-2,5-diones and 3-arylpyrolidine-2,5-diones by reaction of nitroketene dithioacetal with arylacetonitriles

The reaction of nitroketene dithioacetal (1a), i.e., 2,2-bis(methylthio)-1-nitroethylene, with arylacetonitriles (2a-I) in the presence of the base like sodium hydroxide gave 4-nitrobut-2-enenitriles (3a-I) which were convened into 5-hydroxyimino-4-methylthio-3-phenyl-3-pyrrolin-2-ones (4a-i) under refluxing in methanol. Title compounds (5a-i) were readily obtained by the treatment of 4a-i with hydrochloric acid and were finally led to N-methylated products (6a-I) with methyl iodide. The reduction of maleimides (4 - 6) with zinc dust in acetic acid afforded the corresponding 3-arylpyrrolidine-2,5-diones (7a-i) that can be convened to pharmacologycally active compounds like mesembrines.