49621-49-0

Basic information

• Product Name: 3,4,5-TRIMETHOXYCINNAMYLNITRILE
• Synonyms: 3,4,5-TRIMETHOXYCINNAMYLNITRILE
• CAS NO: 49621-49-0
• Molecular Formula: C₁₂H₁₃NO₃
• Molecular Weight: 219.24
• Mol File: 49621-49-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,4,5-TRIMETHOXYCINNAMYLNITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5-TRIMETHOXYCINNAMYLNITRILE(49621-49-0)
• EPA Substance Registry System: 3,4,5-TRIMETHOXYCINNAMYLNITRILE(49621-49-0)

Safety Data

• Hazardous Substances Data: 49621-49-0(Hazardous Substances Data)

Upstream product

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 16640-68-9 cyanomethylene triphenylphosphorane 
• 2537-48-6 diethyl 1-cyanomethylphosphonate 

Downstream Products

• 49621-50-3 3-(3,4,5-Trimethoxyphenyl)propionitrile 

Relevant articles and documents

8-Hydroxyquinolin-2(1H)-one analogues as potential β2-agonists: Design, synthesis and activity study

β2-Agonists that bind to plasmalemmal β2-adrenoceptors causing cAMP accumulation are widely used as bronchodilators in chronic respiratory diseases. Here, we designed and synthesized a group of 8-hydroxyquinolin-2(1H)-one analogues and studied their β2-agonistic activities with a cellular cAMP assay. Compounds B05 and C08 were identified as potent (EC50 2-agonists among the compounds tested. They behaved as partial β2-agonists in non-overexpressed HEK293 cells, and possessed rapid smooth muscle relaxant actions and long duration of action in isolated guinea pig tracheal strip preparations. In summary, B05 and C08 are β2-agonists with potential applicability in chronic respiratory diseases.

Kinetic study of microwave-assisted Wittig reaction of stabilised ylides with aromatic aldehydes

The Wittig reaction of a pool of stabilised ylides and aromatic aldehydes was carried out in a microwave oven. Only a few minutes were needed for high conversion rates under microwave heating in comparison to hour time with traditional methods.