49674-15-9

Basic information

• Product Name: 3-Bromo-5-nitrobenzonitrile
• Synonyms: 3-Bromo-5-nitrobenzonitrile;1-Bromo-3-cyano-5-nitrobenzene;3-Nitro-5-bromobenzonitrile;Benzonitrile, 3-broMo-5-nitro-
• CAS NO: 49674-15-9
• Molecular Formula: C₇H₃BrN₂O₂
• Molecular Weight: 227.01
• Product Categories: blocks;Carboxes;Pyridines
• Mol File: 49674-15-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 84-85℃
• Boiling Point: 283℃
• Flash Point: 125℃
• Appearance: /
• Density: 1.81
• Vapor Pressure: 0.00323mmHg at 25°C
• Refractive Index: 1.638
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-Bromo-5-nitrobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-5-nitrobenzonitrile(49674-15-9)
• EPA Substance Registry System: 3-Bromo-5-nitrobenzonitrile(49674-15-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 49674-15-9(Hazardous Substances Data)

Usage

General Description

3-Bromo-5-nitrobenzonitrile is a chemical compound with the molecular formula C7H3BrN2O2. It is a yellow crystalline solid that is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. It is a versatile building block in organic synthesis, often used in the preparation of biologically active compounds. 3-Bromo-5-nitrobenzonitrile is highly reactive and can undergo various chemical reactions, such as nucleophilic substitution, and is commonly used in medicinal chemistry research. It is important to handle this compound with care, as it is toxic and may cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C7H3BrN2O2/c8-6-1-5(4-9)2-7(3-6)10(11)12/h1-3H

Upstream product

• 17601-94-4 2-amino-3-bromo-5-nitrobenzonitrile 
• 51339-40-3 3-bromo-5-nitrobenzoyl chloride 
• 54321-80-1 3-bromo-5-nitrobenzamide 
• 6307-83-1 3-bromo-5-nitro-benzoic acid 

Downstream Products

• 49674-16-0 3-amino-5-bromo-benzonitrile 
• 1312923-96-8 3-(2-(5-methylpyridin-2-yl)ethynyl)-5-nitrobenzonitrile 
• 1031370-96-3 3-(2-(pyridin-2-yl)ethynyl)-5-nitrobenzonitrile 
• 1312923-86-6 3-(2-(2-methylthiazol-4-yl)ethynyl)-5-nitrobenzonitrile 
• 1312923-92-4 3-(2-(6-methylpyridin-2-yl)ethynyl)-5-nitrobenzonitrile 
• 1386459-80-8 3-bromo-5-(1H-tetrazol-5-yl)-phenylamine hydrochloride 
• 1445791-76-3 3-((4-fluorophenyl)amino)-5-nitrobenzonitrile 
• 1445791-86-5 3-nitro-5-((3-(trifluoromethyl)phenyl)amino)benzonitrile 
• 1445788-38-4 7-(2,4-dimethoxypyrimidin-5-yl)-4-((3-((4-fluorophenyl)amino)-5-(2H-tetrazol-5-yl)phenyl)amino)quinoline-3-sulfonamide 
• 1445791-78-5 N-(4-fluorophenyl)-3-nitro-5-(2H-tetrazol-5-yl)aniline 
• 1445788-40-8 7-(2,4-dimethoxypyrimidin-5-yl)-4-((3-((4-fluorophenyl)amino)-5-(2H-tetrazol-5-yl)phenyl)amino)quinoline-3-sulfonamide 
• 1445791-88-7 N-hydroxy-3-nitro-5-((3-(trifluoromethyl)phenyl)amino)benzimidamide 
• 1445880-68-1 3-(cyclopent-1-en-1-yl)-5-nitrobenzonitrile 
• 1445879-44-6 N-cyclopropyl-7-(2,4-dimethoxypyrimidin-5-yl)-4-((3-((4-fluorophenyl)amino)-5-(2H-tetrazol-5-yl)phenyl)amino)quinoline-3-sulfonamide 

Relevant articles and documents

COMPOUNDS, COMPOSITIONS AND METHODS OF USE

Herein, compounds, compositions and methods for modulating inclusion formation and stress granules in cells related to the onset of neurodegenerative diseases, musculoskeletal diseases, cancer, ophthalmological diseases, and viral infections are described.

Potent mGluR5 antagonists: Pyridyl and thiazolyl-ethynyl-3,5-disubstituted- phenyl series

We report the synthesis of four series of 3,5-disubstituted-phenyl ligands targeting the metabotropic glutamate receptor subtype 5: (2-methylthiazol-4-yl) ethynyl (1a-j,), (6-methylpyridin-2-yl)ethynyl (2a-j), (5-methylpyridin-2-yl) ethynyl (3a-j,), and (pyridin-2-yl)ethynyl (4a-j,). The compounds were evaluated for antagonism of glutamate-mediated mobilization of internal calcium in an mGluR5 in vitro assay. All compounds were found to be full antagonists and exhibited low nanomolar to subnanomolar activity.