500011-86-9

Basic information

• Product Name: 3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid
• Synonyms: 3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid;3-broMo-1-(3-chloro-2-pyridinyl)-1H-Pyrazole-5-carboxylic acid;3-Bromo-1-(3-chloropyridin-2-yl);3-Bromo-1-(3-Chloro-2-Pyridinyl)-1H-Pyrazole
• CAS NO: 500011-86-9
• Molecular Formula: C₉H₅BrClN₃O₂
• Molecular Weight: 302.5119
• Mol File: 500011-86-9.mol
• Article Data: 48

Chemical Properties

• Melting Point: 197-200 °C
• Boiling Point: 477.4±45.0 °C(Predicted)
• Appearance: /
• Density: 1.92±0.1 g/cm3(Predicted)
• Vapor Pressure: 0Pa at 20℃
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 2.39±0.36(Predicted)
• Water Solubility: 8.84g/L at 20.3℃
• CAS DataBase Reference: 3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid(500011-86-9)
• EPA Substance Registry System: 3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid(500011-86-9)

Safety Data

• Hazardous Substances Data: 500011-86-9(Hazardous Substances Data)

Usage

Flammability and Explosibility

Notclassified

Upstream product

• 500011-85-8 2-(3-bromo-1H-pyrazol-1-yl)-3-chloropyridine 
• 124-38-9 carbon dioxide 
• 500011-92-7 5-bromo-2-(3-chloro-pyridin-2-yl)-2H-pyrazole-3-carboxylic acid ethyl ester 
• 1045077-26-6 3-bromo-1-(3-chloropyridine-2-yl)-1H-pyrazole-5-carboxylic acid methyl ester 
• 500011-91-6 5-bromo-2-(3-chloro-pyridin-2-yl)-3,4-dihydro-2H-pyrazole-3-carboxylic acid ethyl ester 
• 500011-88-1 2-(3-chloro-pyridin-2-yl)-5-oxo-pyrazolidine-3-carboxylic acid ethyl ester 
• 22841-92-5 (3-chloro-2-pyridyl)hydrazine 
• 2402-77-9 2,3-dichloro-pyridine 
• 500011-88-1 ethyl 1-(3-chloropyridin-2-yl)-3-hydroxy-4,5-dihydro-1H-pyrazole-5-carboxylate 
• 22841-92-5 3-chloro-2(1H)-pyridinone hydrazone 
• 500011-89-2 ethyl 5-chloro-2-(3-chloropyridin-2-yl)-3,4-dihydro-2H-pyrazole-3-carboxylate 
• 500011-95-0 2-(3-chloropyridin-2-yl)-5-hydroxypyrazole-3-carboxylic acid ethyl ester 
• 1905484-46-9 3-bromo-1H-pyrazole-5-carboxylic acid 
• 1150164-31-0 ethyl 1-(3-chloropyridin-2-yl)-5-methyl-1H-pyrazole-4-carboxylate 

Downstream Products

• 736995-63-4 2-[1-(3-chloropyridine-2-yl)-3-bromo-1H-pyrazole-5-yl]-6-iodo-8-methyl-4H-3,1-benzoxazine-4-one 
• 500008-45-7 rynaxypyr 
• 736994-63-1 cyantraniliprole 
• 1072138-15-8 C₂₂H₁₈Br₃ClN₆O₄ 
• 1072330-79-0 C₂₁H₁₆Br₃ClN₆O₄ 
• 1373758-63-4 3-bromo-N-(4-chloro-2-(hydroxymethyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 1373758-65-6 3-bromo-N-(4-chloro-2-formyl-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 1379663-66-7 3-bromo-N'-(4-chlorophenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbohydrazide 
• 1379663-68-9 3-bromo-1-(3-chloropyridin-2-yl)-N'-(2,4-dichlorophenyl)-1H-pyrazole-5-carbohydrazide 
• 1379663-69-0 3-bromo-1-(3-chloropyridin-2-yl)-N'-(2,6-dimethylphenyl)-1H-pyrazole-5-carbohydrazide 
• 1352547-43-3 N'-(2-methylphenyl)-N-[1-(3-chloro-2-pyridyl)-3-bromo-1H-pyrazole-5-carbonyl]thiourea 
• 1352547-45-5 N'-(2-trifluoromethylphenyl)-N-[1-(3-chloro-2-pyridyl)-3-bromo-1H-pyrazole-5-carbonyl]thiourea 
• 1352547-44-4 N'-(2-chlorophenyl)-N-[1-(3-chloro-2-pyridyl)-3-bromo-1H-pyrazole-5-carbonyl]thiourea 
• 1352547-48-8 N'-(2-nitrophenyl)-N-[1-(3-chloro-2-pyridyl)-3-bromo-1H-pyrazole-5-carbonyl]thiourea 

Relevant articles and documents

Design, synthesis and insecticidal-activity evaluation of N-pyridylpyrazolo-5-methyl amines and its derivatives

In searching for novel insecticidal leads, a series of N-pyridylpyrazolo-5-methyl amines and their derivatives were designed and synthesized. Among the 22 target compounds obtained, bioassays indicated that some of the target compounds exhibited good insecticidal activities against Plutella xylostella (P. xylostella) and Spodoptera frugiperda (S. frugiperda). In particular, compound 9j revealed the best insecticidal activity against P. xylostella, with a LC50 value of 22.11 mg/L, and compound 9q had the best insecticidal activity against S. frugiperda which with 73.99% of mortality rate at 100 mg/L. Structure-activity relationship (SAR) analysis showed that 4-CF3 at the position of R1 linked with N-pyridylpyrazole via amide bond could enhance the insecticidal activity of the target compounds. This study provides valuable clues for the further design and optimization of N-pyridylpyrazole derivatives.

Method for synthesizing chlorantraniliprole

A solvent containing 2 - amino -3 - methylbenzoic acid is stirred, N - methyl -3 - methyl -2 - amino - benzamide is dissolved in alkali liquor in a stirring reaction process, and reacted with NCS to obtain N - methyl -3 - methyl -2 - amino -5 - chloro - benzamide. The reaction of the bromination reaction, the oxidation reaction and the condensation reaction is carried out by cooperation of a catalyst so as to obtain chlorantraniliprole. By optimizing the preparation steps of chlorantraniliprole, the whole process is relatively simple in process steps, the post-treatment is simple, intermediate products can be obtained directly after the single step is finished, high environmental control requirements are not needed in the whole synthesis step, and industrialization can be conveniently realized.

Preparation method of key intermediate K acid of chlorantraniliprole

The invention relates to a preparation method of a key intermediate K acid of chlorantraniliprole. The preparation method has the advantages of fewer reaction sites, less impurity generation and capability of realizing efficient, green and environment-friendly preparation of K acid. According to the method, ethyl acetoacrylate is used as a raw material and subjected to carbonyl protection, cyclization, deprotection, oxidation and bromination so as to finally prepare the K acid. The method has the advantages of high cyclization yield, good selectivity and high product purity.