5002-07-3

Basic information

• Product Name: 1-(4'-CHLORO-BIPHENYL-4-YL)-ETHANONE
• Synonyms: AKOS BAR-0211;1-(4'-CHLORO[1,1'-BIPHENYL]-4-YL)ETHANONE;1-(4'-CHLORO[1,1-BIPHENYL]-4-YL)ETHANONE;1-(4'-CHLORO-BIPHENYL-4-YL)-ETHANONE;4-Acetyl-4'-chlorobiphenyl;1-{4'-chloro-[1,1'-biphenyl]-4-yl}ethan-1-one
• CAS NO: 5002-07-3
• Molecular Formula: C₁₄H₁₁ClO
• Molecular Weight: 230.69
• Mol File: 5002-07-3.mol
• Article Data: 91

Chemical Properties

• Boiling Point: 353.2 °C at 760 mmHg
• Flash Point: 193.2 °C
• Appearance: /
• Density: 1.163 g/cm³
• CAS DataBase Reference: 1-(4'-CHLORO-BIPHENYL-4-YL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4'-CHLORO-BIPHENYL-4-YL)-ETHANONE(5002-07-3)
• EPA Substance Registry System: 1-(4'-CHLORO-BIPHENYL-4-YL)-ETHANONE(5002-07-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 5002-07-3(Hazardous Substances Data)

Usage

General Description

1-(4'-chloro-biphenyl-4-yl)-ethanone, also known as 4'-chloroacetophenone, is a chemical compound with the molecular formula C14H11ClO. It is an aromatic ketone with a chlorine atom attached to the 4' position of the biphenyl ring. 1-(4'-CHLORO-BIPHENYL-4-YL)-ETHANONE is commonly used in the synthesis of pharmaceuticals, agrochemicals, and dyes. It is also used as a flavoring agent in the food industry. 1-(4'-chloro-biphenyl-4-yl)-ethanone is known for its strong odor and is classified as a toxic and irritant substance. Due to its potential health hazards, it should be handled with caution and in compliance with safety regulations.

Upstream product

• 75-36-5 acetyl chloride 
• 2051-62-9 4'-biphenyl chloride 
• 74-90-8 hydrogen cyanide 
• 74415-07-9 2-(4'-Chloro-biphenyl-4-yl)-2-hydroxy-propionitrile 
• 1679-18-1 4-Chlorophenylboronic acid 
• 220820-74-6 5-[2-(4-bromo-phenyl)-2-methyl-[1,3]dithian-4-yl]-pentanoic acid 
• 89566-59-6 di-(p-chlorophenyl)borinic acid 
• 99-90-1 para-bromoacetophenone 
• 13329-40-3 4-Iodoacetophenone 
• 109613-00-5 4-acetophenyl triflate 
• 99-91-2 para-chloroacetophenone 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 18373-75-6 hexakis-(4-chloro-phenyl)-cyclotrisiloxane 
• 5575-51-9 tris(4-chlorophenyl)bismuthane 

Downstream Products

• 5748-41-4 4'-chlorobiphenyl-4-carboxylic acid 
• 1224164-01-5 C₂₀H₁₈ClNO₂S 
• 1416355-04-8 C₁₈H₁₃ClN₂O₅ 
• 69231-77-2 1-[1-(4'-chloro[1,1']biphenyl-4-yl)ethyl]piperazine 

Relevant articles and documents

Iminophosphine-palladium(0) complexes as highly active catalysts in the Suzuki reaction. Synthesis of undecaaryl substituted corroles

The iminophosphine-palladium(0) complex [Pd(dmfu)(P-N)] [dmfu=dimethyl fumarate; P-N=2-(PPh2)C6H4-1-CH=NC 6H4-4-OMe] is a very efficient catalyst for the Suzuki coupling. In the reaction of aryl bromides with phenylboronic acid, turnover numbers up to ca. 200,000 are obtained at 110°C in 2h. Good rates are obtained also with the sterically hindered and electronically deactivated 2-bromo-1,3,5-trimethylbenzene. The complex is able to catalyze the exhaustive arylation of 2,3,7,8,12,13,17,18-octabromo-5,10,15-triphenylcorroleCu(III) to yield the corresponding undecaaryl substituted derivative.

Synthesis and biological evaluation of 3,5-substituted pyrazoles as possible antibacterial agents

The emergence of multi-drug resistant bacteria has increased the need for novel antibiotics to help overcome what may be considered the greatest threat to modern medicine. Here we report the synthesis of fifteen novel 3,5-diaryl-1H- pyrazoles obtained via

Highly efficient palladium-catalyzed cross-coupling of diarylborinic acids with arenediazoniums for practical diaryl synthesis

A highly efficient cross-coupling of cost-effective diarylborinic acids with both isolatable and latent arenediazoniums, i.e. tetrafluoroborates and aryltriazenes, respectively, has been developed with a practical palladium catalyst system under base-free conditions in open flask at room temperature. A variety of electronically and sterically various biaryls, in particular, those bearing a coordinative ortho-substituent, could be obtained in good to excellent yields by using 0.3 mol% palladium acetate as catalyst. Features of the protocol including cost-effectiveness of diarylborinic acids, efficacy to heteroatom ortho-substituted substrates and high chemoselectivity to aryl chlorides have been clearly demonstrated in practical synthesis of fungicide Boscalid.

Desulfurization of Diaryl(heteroaryl) Sulfoxides with Benzyne

Two benzyne-enabled desulfurization reactions have been demonstrated which convert diaryl sulfoxides and heteroaryl sulfoxides to biaryls and desulfurized heteroarenes, respectively. The reaction accessing biaryls tolerates a variety of functional groups, such as halides, pseudohalides, and carbonyls. Mechanistic studies reveal that both reactions proceed via a common assembly process but divergent disassemblies of the generated tetraaryl(heteroaryl) sulfuranes.