500791-70-8

Basic information

• Product Name: (5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]-methanone ethanedioate
• Synonyms: (5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]-methanone ethanedioate;(5-AMino-2-butylbenzofuran-3-yl)(4-(3-(dibutylaMino)propoxy)phenyl)Methanone oxalate;(5-aMino-2-butylbenzofuran-3-yl)(4-(3-(dibutylaMino)propoxy)phenyl)Methanone dioxalate;(5-aMino-2-butyl-3-benzofuranyl)[4-[3-(dibutylaMino) propoxy]phenyl]-Methanone dioxalate;Des(Methylsulfonyl) Dronedarone Oxalate;Dronedarone Hydrochloride IMpurity A;(4-(3-(dibutylamino);(5-Amino-2-butylbenzofuran-3-yl)
• CAS NO: 500791-70-8
• Molecular Formula: C30H42N2O3.2(C2H2O4)
• Molecular Weight: 658.75
• EINECS: 1806241-263-5
• Mol File: 500791-70-8.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: (5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]-methanone ethanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: (5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]-methanone ethanedioate(500791-70-8)
• EPA Substance Registry System: (5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]-methanone ethanedioate(500791-70-8)

Safety Data

• Hazardous Substances Data: 500791-70-8(Hazardous Substances Data)

Usage

Description

(5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]-methanone ethanedioate is a complex organic compound with a unique chemical structure. It is characterized by the presence of an amino group, a butyl group, a benzofuranyl moiety, and a dibutylaminopropoxyphenyl group. (5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]-methanone ethanedioate is likely to have specific chemical and physical properties that make it suitable for various applications.
Used in Pharmaceutical Industry:
(5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]-methanone ethanedioate is used as an intermediate in the synthesis of pharmaceutical compounds for the treatment of various diseases and conditions.
Used in Chemical Synthesis:
(5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]-methanone ethanedioate is used as a building block in the synthesis of other complex organic molecules, such as dyes, pigments, and specialty chemicals.
Used in Research and Development:
(5-Amino-2-butyl-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]-methanone ethanedioate is used as a research compound to study its chemical properties, reactivity, and potential applications in various fields.

InChI:InChI=1/C30H42N2O3.2C2H2O4/c1-4-7-11-28-29(26-22-24(31)14-17-27(26)35-28)30(33)23-12-15-25(16-13-23)34-21-10-20-32(18-8-5-2)19-9-6-3;2*3-1(4)2(5)6/h12-17,22H,4-11,18-21,31H2,1-3H3;2*(H,3,4)(H,5,6)

Upstream product

• 100-07-2 4-methoxy-benzoyl chloride 
• 141645-23-0 (2-butyl-5-nitrobenzofuran-3-yl)(4-(3-(dibutylamino)propoxy)phenyl)methanone 
• 144-62-7 oxalic acid 
• 133238-87-6 2-(n-butyl)-5-nitrobenzofuran 
• 141645-16-1 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran 
• 141627-42-1 (2-butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone 
• 141644-91-9 (5-amino-2-butyl-benzofuran-3-yl)-[4-(3-dibutylamino-propoxy)-phenyl]-methanone 
• 36421-15-5 dibutyl-(3-chloro-propyl)-amine 
• 1365546-07-1 C₃₈H₄₄N₂O₅ 
• 6153-56-6 oxalic acid dihydrate 
• 1365546-05-9 2-(-2-butyl-1-benzofuran-5-yl)-1H-isoindole-1,3(2H)dione 
• 1365546-06-0 3-[4-(3-chloropropoxy)benzoyl]-2-n-butylbenzofuran-5-yl-1H-isoindole-1,3(2H)dione 
• 526196-90-7 2-n-butyl-5-aminobenzofuran hydrochloride 
• 65136-48-3 4-(3-chloropropoxy)benzoic acid chloride 

Downstream Products

• 141644-91-9 (5-amino-2-butyl-benzofuran-3-yl)-[4-(3-dibutylamino-propoxy)-phenyl]-methanone 
• 141625-93-6 dronedarone hydrochloride 
• 141626-57-5 N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide 
• 141626-36-0 dronedarone 

Relevant articles and documents

2-butyl-3 - (4-substituted propoxy benzoyl) - 5-substituted aminobenzofuran and its application

The invention discloses 2-n-butyl-3-(4-subsitituted propylbenzoyl)-5-substituted amino benzofuran and application thereof. The 2-n-butyl-3-(4-subsitituted propylbenzoyl)-5-substituted amino benzofuran can be used for preparing dronedarone and pharmaceutic

Identification and characterization of potential impurities of dronedarone hydrochloride

Six potential process related impurities were detected during the impurity profile study of an antiarrhythmic drug substance, Dronedarone (1). Simple high performance liquid chromatography and liquid chromatography-mass spectrometry methods were used for the detection of these process impurities. Based on the synthesis and spectral data (MS, IR, 1H NMR, 13C NMR, and DEPT), the structures of these impurities were characterized a s 5-amino-3-[4-(3-di-n-butylaminopropoxy)benzoyl]-2-n-butylbenzofuran (impurity I); N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N- (methylsulfonyl)-methanesulfonamide (impurity II); N-(2-butyl-3-(4-(3- (dibutylamino)propoxy)benzoyl)benzofuran-5-yl)-1-chloromethanesulfonamide (impurity III); N-{2-propyl-3-[4-(3-dibutylaminopropoxy)benzoyl]benzofuran-5-yl} - methanesulfonamide (impurity IV); N-(2-butyl-3-(4-(3-(dibutylamino)propoxy) benzoyl)benzofuran-5-yl)-formamide (impurity V); and (2-butyl-5-((3- (dibutylamino)propyl)amino)benzofuran-3-yl)(4-(3- (dibutylamino)propoxy)phenyl) methanone (impurity VI). The synthesis and characterization of these impurities are discussed in detail.

Process for obtaining dronedarone

The present invention provides a process for obtaining dronedarone or salts thereof characterized in that in an organic phase comprising one or more non-polar solvents, 5-amino-3-[4-(3-di-n-butylaminopropoxy)benzoyl]-2-n-butyl-benzofuran is reacted with methane sulfonyl chloride without the addition of a base. The invention also provides a process for obtaining intermediates of dronedarone environmentally friendly and industrially viable..