501-81-5 Usage
Description
3-Pyridylacetic acid, also known as 3-(3-pyridyl)propanoic acid, is a monocarboxylic acid derived from acetic acid with a (pyridin-3-yl) group substitution. It is a metabolite of nicotine and other tobacco alkaloids, characterized by its off-white to light yellow solid appearance.
Uses
Used in Pharmaceutical Industry:
3-Pyridylacetic acid is used as an intermediate compound for the synthesis of various pharmaceuticals, particularly those targeting the central nervous system. Its unique chemical structure allows it to interact with specific receptors, making it a valuable building block for the development of new drugs.
Used in Chemical Research:
In the field of chemical research, 3-Pyridylacetic acid serves as a key component in the study of nicotine and tobacco alkaloids metabolism. Its role in understanding the biological pathways and effects of these substances contributes to the development of potential therapeutic strategies and addiction treatments.
Used in Analytical Chemistry:
3-Pyridylacetic acid is utilized as a derivatizing agent in analytical chemistry, particularly for the detection and quantification of amines and other nitrogen-containing compounds. Its reactivity with these compounds allows for improved sensitivity and selectivity in analytical techniques, such as gas chromatography and mass spectrometry.
Used in Material Science:
In material science, 3-Pyridylacetic acid can be employed as a building block for the development of novel materials with specific properties, such as conductivity or magnetism. Its unique chemical structure can be exploited to create new polymers, coordination complexes, or other advanced materials with potential applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 501-81-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,0 and 1 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 501-81:
(5*5)+(4*0)+(3*1)+(2*8)+(1*1)=45
45 % 10 = 5
So 501-81-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H7NO2.ClH/c9-7(10)4-6-2-1-3-8-5-6;/h1-3,5H,4H2,(H,9,10);1H
501-81-5Relevant articles and documents
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McKennis,jr. et al.
, p. 3974 (1960)
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Pd(OH)2/C, a Practical and Efficient Catalyst for the Carboxylation of Benzylic Bromides with Carbon Monoxide
Wakuluk-Machado, Anne-Marie,Dewez, Damien F.,Baguia, Hajar,Imbratta, Miguel,Echeverria, Pierre-Georges,Evano, Gwilherm
, p. 713 - 723 (2020/02/04)
A simple, efficient, cheap, and broadly applicable system for the carboxylation of benzylic bromides with carbon monoxide and water is reported. Upon simple reaction with only 2.5 wt % of Pearlman's catalyst and 10 mol % of tetrabutylammonium bromide in tetrahydrofuran at 110 °C for 4 h, a range of benzylic bromides can be smoothly converted to the corresponding arylacetic acids in good to excellent yields after simple extraction and acid-base wash. The reaction was found to be broadly applicable, scalable, and could be successfully extended to the use of ex situ-generated carbon monoxide and applied to the synthesis of the nonsteroidal anti-inflammatory drug diclofenac.
Neuropeptide Y antagonists
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Page column 23-24, (2010/02/05)
The compound is a neuropeptide Y antagonist and is effective in treating feeding disorders, cardiovascular diseases and other physiological disorders.
