501083-05-2Relevant articles and documents
Studies on the synthesis of estrogen-GHRPS linkers
Wang, Chao,Zhao, Ming,Cui, Weina,Yang, Jian,Peng, Shiqi
, p. 1633 - 1641 (2007/10/03)
A series of linkers consisted of estrone, estradiol, and GHRPS (growth hormone releasing peptides) were prepared with carboxyl-methyl or succinyl as the conjugated group. As a protective group in the side chain of Tyr, the Dcb (2,6-dichlorobenzyl) in the intermediates which is unstable to HF can be removed in high yield in the presence of Pd/C (10%), H2, and 4.4% formic acid in methanol.