501682-72-0Relevant articles and documents
Enantioselective Reductive Divinylation of Unactivated Alkenes by Nickel-Catalyzed Cyclization Coupling Reaction
Peng, Xuejing,Qiao, Jin-Bao,Shu, Xing-Zhong,Yao, Qi-Wei,Zhang, Ya-Qian,Zhao, Zhen-Zhen
supporting information, p. 12961 - 12967 (2021/09/03)
Catalytic asymmetric dicarbofunctionalization of tethered alkenes has emerged as a promising tool for producing chiral cyclic molecules; however, it typically relies on aryl-tethered alkenes to form benzene-fused compounds. Herein, we report an enantioselective cross-electrophile divinylation reaction of nonaromatic substrates, 2-bromo-1,6-dienes. The approach thus offers a route to new chiral cyclic architectures, which are key structural motifs found in various biologically active compounds. The reaction proceeds under mild conditions, and the use of chiral t-Bu-pmrox and 3,5-difluoro-pyrox ligands resulted in the formation of divinylated products with high chemo-, regio-, and enantioselectivity. The method is applicable for the incorporation of chiral hetero- and carbocycles into complex molecules.
Reactivity of Arynes for Arene Dearomatization
Karmakar, Rajdip,Le, Anh,Xie, Peipei,Xia, Yuanzhi,Lee, Daesung
supporting information, p. 4168 - 4172 (2018/07/29)
An unprecedented aryne-mediated dearomatization reaction is described. An aryne intermediate generated from arenesulfonyl ynamide-tethered triynes and tetraynes reacts with both the π-systems of a tethered alkene and the arenesulfonyl group to generate cy
