501948-42-1Relevant articles and documents
Development of a practical synthesis of STA-5312, a novel indolizine oxalylamide microtubule inhibitor
Li, Hao,Xia, Zhiqiang,Chen, Shoujun,Koya, Keizo,Ono, Mitsunori,Sun, Lijun
, p. 246 - 250 (2012/12/26)
An efficient synthesis of the novel microtubule inhibitor STA-5312(3-[(4-cyanophenyl)methyl]-N-3-methyl-5-isothiazolyl) -α-oxo-1-indolizineacetamide) was developed. A novel DMF/ Me 2SO4 directed regioselective synthesis of the 3-(4-c
Controlling chemoselectivity-application of DMF di-t-butyl acetal in the regioselective synthesis of 3-monosubstituted indolizines
Xia, Zhiqiang,Przewloka, Teresa,Koya, Keizo,Ono, Mitsunori,Chen, Shoujun,Sun, Lijun
, p. 8817 - 8820 (2007/10/03)
Among a number of DMF dialkyl acetals investigated for the regioselective synthesis of 3-acylindolizines, the di-t-butyl acetal, via its iminium intermediate readily formed in situ, provides the highest chemoselectivity for the intermolecular cyclization of picolinium salts. DMF di-t-butyl acetal was applied to the syntheses of a variety of 3-acylated indolizines including alkyl, aryl, and heteroaryl substituents.
1-Glyoxlylamide indolizines for treating cancer
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, (2008/06/13)
Disclosed is a compound represented by Structural Formula (I): Ring A is substituted or unsubstituted and optionally fused to an aryl group. Z1 and Z2 are independently ═O, ═S, ═N—OR12 or ═NR12 R1 an