502493-99-4Relevant articles and documents
Synthesis of a carbohydrate-derived hydroxamic acid inhibitor of the bacterial enzyme (LpxC) involved in lipid A biosynthesis
Li, Xuechen,Uchiyama, Taketo,Raetz, Christian R. H.,Hindsgaul, Ole
, p. 539 - 541 (2007/10/03)
(Matrix presented) The enzyme LpxC (UDP-3-O-[(R)-3-hydroxymyristoyl] -GlcNAc deacetylase) catalyzes the second step of lipid A biosynthesis and is essential for bacterial growth. A GlcNAc-derived hydroxamic acid inhibitor 8 of this enzyme was synthesized