502584-83-0

Basic information

• Product Name: 5,8-Phthalazinedione, 6-chloro-7-(phenylamino)-
• CAS NO: 502584-83-0
• Molecular Formula: C14H8ClN3O2
• Molecular Weight: 285.689
• Mol File: 502584-83-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5,8-Phthalazinedione, 6-chloro-7-(phenylamino)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5,8-Phthalazinedione, 6-chloro-7-(phenylamino)-(502584-83-0)
• EPA Substance Registry System: 5,8-Phthalazinedione, 6-chloro-7-(phenylamino)-(502584-83-0)

Safety Data

• Hazardous Substances Data: 502584-83-0(Hazardous Substances Data)

Upstream product

• 89898-86-2 5-nitrophthalazine 
• 502584-74-9 5,8-diaminophthalazine 
• 502584-69-2 8-nitrophthalazine-5-amine 
• 102072-85-5 DA 3044 
• 62-53-3 aniline 

Relevant articles and documents

Synthesis and cytotoxicity evaluation of 6,11-dihydro-pyridazo- and 6,11-dihydro-pyrido[2,3-b]phenazine-6,11-diones

The 6,11-dihydro-pyridazo[2,3-b]phenazine-6,11-dione and 6,11-dihydro-pyrido[2,3-b]phenazine-6,11-dione derivatives were synthesized from 6,7-dichloro-5,8-phthalazinedione and 6,7-dichloro-5,8-quinolinedione, respectively, producing a series of new anticancer drugs. The cytotoxic activities of the prepared compounds were evaluated by a SRB (Sulforhodamine B) assay against the following tumor cell lines: A459 (human lung), SK-OV-3 (human ovarian), SK-MEL-2 (human melanoma), XF498 (human CNS), and HCT 15 (human colon). Almost all the derivatives of the 6,11-dihydro-pyridazo[2[,3-b] phenazine-6,11-dione and 6,11-dihydro-pyrido[2,3-b]phenazine-6,11-dione, tetracyclic heteroquinone analogues with four or three nitrogen atoms, exhibited excellent cytotoxicity on almost all the human tumor cell lines tested. Specifically, 6,11-dihydro-pyridazo[2,3-b]phenazine-6,11-dione (4a) exhibited potent activity against all the tumor cell lines, and in particular, its cytotoxic effect against HCT 15 (ED50=0.004 μg/mL) was 25 times greater than that of doxorubicin (ED50=0.093 μg/mL).