50270-27-4Relevant articles and documents
SHP2 INHIBITORS AND USES THEREOF
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Page/Page column 122-123, (2021/04/02)
Compounds of Formula 1 as inhibitors of protein tyrosine phosphatase SHP2 are disclosed. The pharmaceutical compositions comprising compounds of Formula 1, methods of synthesis of these compounds, methods of treatment for diseases associated with the aberrant activity of SHP2 such as cancer using these compounds or compositions containing these compounds are also disclosed.
Substituted pyrazole[3,4-d]pyrimidine compound as well as preparation method and application thereof
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Paragraph 0058-0060, (2020/10/20)
The invention discloses a substituted pyrazole[3,4-d]pyrimidine compound as well as a preparation method and application thereof. The structure of the compound is shown as a formula (I) or a formula (II). The compound provided by the invention has a good inhibition effect on phosphodiesterase type I (PDE1), and can be used as a phosphodiesterase type I inhibitor; meanwhile, a medicine prepared from the compound has a relatively good curative effect on pulmonary arterial hypertension and idiopathic pulmonary fibrosis; therefore, the compound provided by the invention has important medicinal value and wide application prospect in preparing medicines for treating pulmonary arterial hypertension and idiopathic pulmonary fibrosis. In addition, the compound disclosed by the invention is novel instructure, simple in preparation method and suitable for large-scale industrial production and application.
COMPOUNDS
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Page/Page column 197, (2017/02/09)
Disclosed are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis(ALS).