503174-32-1

Basic information

• Product Name: 2(5H)-Furanone, 5-ethyl-5-hydroxy-3-[4-(methylthio)phenyl]-4-phenyl-
• CAS NO: 503174-32-1
• Molecular Formula: C19H18O3S
• Molecular Weight: 326.416
• Mol File: 503174-32-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2(5H)-Furanone, 5-ethyl-5-hydroxy-3-[4-(methylthio)phenyl]-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(5H)-Furanone, 5-ethyl-5-hydroxy-3-[4-(methylthio)phenyl]-4-phenyl-(503174-32-1)
• EPA Substance Registry System: 2(5H)-Furanone, 5-ethyl-5-hydroxy-3-[4-(methylthio)phenyl]-4-phenyl-(503174-32-1)

Safety Data

• Hazardous Substances Data: 503174-32-1(Hazardous Substances Data)

Upstream product

• 562069-20-9 5-ethyl-3-(4-methylsulfanyl-phenyl)-4-phenyl-5H-furan-2-one 
• 562069-41-4 (4-methylsulfanyl-phenyl)-acetic acid 1-benzoyl-propyl ester 

Relevant articles and documents

Synthesis and cyclooxygenase (COX-1/COX-2) inhibiting property of 3,4-diarylfuranones

A series of diarylfuranone including some 5-hydroxy derivatives and naphthofuranones have been synthesized as a unique class of COX-1/COX-2 inhibitors. In contrast to the earlier report of structurally similar rofecoxib, these compounds have been characterized as nonselective but highly potent COX inhibitors. Structure Activity Relationship study confirmed that methoxy and methylsulfanyl moieties are essential for COX activity and replacement or removal of any of this group affect COX-2 potency drastically rather than COX-1 efficacy. Studies on in vitro, in vivo screens and pharmacokinetics are discussed.