5033-22-7

Basic information

• Product Name: (Pyrrolidinyl)(phenyl)sulfone
• Synonyms: (Pyrrolidinyl)(phenyl)sulfone;1-(Phenylsulfonyl)pyrrolidine;(Pyrrolidinyl)(phenyl)sulphone;1-(Phenylsulphonyl)pyrrolidine;(Pyrrolidin-1-yl)(phenyl)sulphone
• CAS NO: 5033-22-7
• Molecular Formula: C₁₀H₁₃NO₂S
• Molecular Weight: 211.28
• Product Categories: blocks;Sulfonamides
• Mol File: 5033-22-7.mol
• Article Data: 37

Chemical Properties

• Melting Point: 46-47°C
• Boiling Point: 341.4°Cat760mmHg
• Flash Point: 160.3°C
• Appearance: /
• Density: 1.264g/cm³
• Vapor Pressure: 8.07E-05mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: Keep Cold
• PKA: -4.91±0.20(Predicted)
• CAS DataBase Reference: (Pyrrolidinyl)(phenyl)sulfone(CAS DataBase Reference)
• NIST Chemistry Reference: (Pyrrolidinyl)(phenyl)sulfone(5033-22-7)
• EPA Substance Registry System: (Pyrrolidinyl)(phenyl)sulfone(5033-22-7)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 5033-22-7(Hazardous Substances Data)

Usage

General Description

(Pyrrolidinyl)(phenyl)sulfone is a chemical compound with the molecular formula C11H13NO2S. It is a sulfone derivative with a pyrrolidine ring and a phenyl group. (Pyrrolidinyl)(phenyl)sulfone has been studied for its potential use as a photo-activated compound in the development of photoresists for microelectronics. It is also known for its application in the field of organic synthesis, particularly in the preparation of various heterocyclic compounds. Additionally, (Pyrrolidinyl)(phenyl)sulfone has been investigated for its potential anti-inflammatory and anti-cancer properties. Further research is ongoing to explore its potential applications in various fields, including medicine and material science.

InChI:InChI=1/C10H13NO2S/c12-14(13,11-8-4-5-9-11)10-6-2-1-3-7-10/h1-3,6-7H,4-5,8-9H2

Upstream product

• 123-75-1 pyrrolidine 
• 98-09-9 benzenesulfonyl chloride 
• 98-10-2 benzenesulfonamide 
• 4724-56-5 1,4-ditosyloxybutane 
• 16851-82-4 N-phenylsulfonylpyrrole 
• 75-09-2 dichloromethane 
• 121434-38-6 phenyliodonium bis(phenylsulfonyl)-methylide 
• 182356-71-4 1-benzenesulfinyl-pyrrolidine 
• 670-98-4 methyl benzenesulfinate 
• 873-55-2 sodium benzenesulfonate 
• 929000-58-8 1-((2-bromophenyl)sulfonyl)pyrrolidine 
• 109-99-9 tetrahydrofuran 
• 62-53-3 aniline 
• 36719-71-8 1-phenyl-3,3-tetramethylenetriazene 

Downstream Products

• 88000-68-4 1-benzenesulfonyl-pyrrolidin-2-one 
• 1219449-56-5 sodium hydroxy(2-(pyrrolidin-1-ylsulfonyl)phenyl)methanesulfonate 
• 1312718-22-1 1,2-bis(2-(pyrrolidin-1-ylsulfonyl)phenyl)disulfane 
• 1312718-23-2 ethyl 2-(3-iodo-2,5-dimethyl-4-(2-(pyrrolidin-1-ylsulfonyl)phenylthio)-1H-pyrrol-1-yl)acetate 

Relevant articles and documents

AEROBIC OXIDATIVE SYNTHESIS OF SULFONAMIDE USING Cu CATALYST

The present invention relates to a method for oxidative synthesis of sulfonamides using copper catalysts. , Oxygen (O) is used. 2 The oxidative synthesis of sulfonamides (1) comprises reacting a 2 th or sulfonyl hydrazide primary amine with a sulfonyl hydrazide (sulfonamide) with a copper catalyst on a solvent under the conditions in which the sulphonamide is fed. The oxidation coupling of the present invention showed extensive substrate ranges in an amine comprising a 2 primary amine, 1 primary amine and amine hydrochloride salt. It is worth notable that non-reactive aliphatic sulfonyl hydrazides in previously reported anaerobic systems can be used for the aerobic oxidation coupling of the present invention. The oxidation coupling of the present invention has been more effective on large scale.

Development of succinimide-based inhibitors for the mitochondrial rhomboid protease PARL

While the biochemistry of rhomboid proteases has been extensively studied since their discovery two decades ago, efforts to define the physiological roles of these enzymes are ongoing and would benefit from chemical probes that can be used to manipulate the functions of these proteins in their native settings. Here, we describe the use of activity-based protein profiling (ABPP) technology to conduct a targeted screen for small-molecule inhibitors of the mitochondrial rhomboid protease PARL, which plays a critical role in regulating mitophagy and cell death. We synthesized a series of succinimide-containing sulfonyl esters and sulfonamides and discovered that these compounds serve as inhibitors of PARL with the most potent sulfonamides having submicromolar affinity for the enzyme. A counterscreen against the bacterial rhomboid protease GlpG demonstrates that several of these compounds display selectivity for PARL over GlpG by as much as two orders of magnitude. Both the sulfonyl ester and sulfonamide scaffolds exhibit reversible binding and are able to engage PARL in mammalian cells. Collectively, our findings provide encouraging precedent for the development of PARL-selective inhibitors and establish N-[(arylsulfonyl)oxy]succinimides and N-arylsulfonylsuccinimides as new molecular scaffolds for inhibiting members of the rhomboid protease family.

Synthesis method of beta-aryl sulfonyl enamine compound

The invention belongs to the technical field of organic synthesis. The invention relates to the technical field of organic synthesis, in particular to a synthesis method of a beta-aryl sulfonyl enamine compound, which comprises the following steps: in an air environment, with a sodium benzenesulfinate derivative and tertiary amine as substrates, carrying out anodic oxidation coupling reaction in amixture of an electrolyte and a solvent to obtain the beta-aryl sulfonyl enamine compound. The synthesis method of the beta-aryl sulfonyl enamine compound provided by the invention is free of metal,oxidant and halogen, the whole synthesis process is harmless to the environment, and a variety of beta-aryl sulfonyl enamine compounds with satisfactory yield can be obtained.