5033-67-0

Basic information

• Product Name: 2-(2-METHYLPHENYL)ACETOPHENONE
• Synonyms: 2-(2-METHYLPHENYL)ACETOPHENONE;UKRORGSYN-BB BBV-5118567
• CAS NO: 5033-67-0
• Molecular Formula: C₁₅H₁₄O
• Molecular Weight: 210.27
• Mol File: 5033-67-0.mol
• Article Data: 49

Chemical Properties

• Boiling Point: 340.1°C at 760 mmHg
• Flash Point: 146.2°C
• Appearance: /
• Density: 1.062g/cm³
• Vapor Pressure: 8.77E-05mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: 2-(2-METHYLPHENYL)ACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-METHYLPHENYL)ACETOPHENONE(5033-67-0)
• EPA Substance Registry System: 2-(2-METHYLPHENYL)ACETOPHENONE(5033-67-0)

Safety Data

• Hazardous Substances Data: 5033-67-0(Hazardous Substances Data)

Usage

General Description

2-(2-Methylphenyl)acetophenone, also known as alpha-Ethyl-2-tolylacetophenone, is a chemical compound with a molecular formula C16H16O. It is a yellow liquid that is commonly used as a flavoring agent and fragrance in the food and cosmetic industries. It is also used in the synthesis of various pharmaceuticals and organic compounds. The compound is classified as a ketone and is derived from the reaction of 2-methylphenylacetic acid with acetic anhydride. 2-(2-Methylphenyl)acetophenone has a strong odor and is considered to be mildly toxic if ingested or inhaled in large quantities. It is important to handle this compound with caution and in accordance with proper safety protocols.

InChI:InChI=1/C15H14O/c1-12-7-5-6-10-14(12)11-15(16)13-8-3-2-4-9-13/h2-10H,11H2,1H3

Upstream product

• 2674-04-6 diphenyl cadmium 
• 10166-09-3 (o-tolyl)acetyl chloride 
• 71-43-2 benzene 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 2093-46-1 2-methylphenyl diazonium tetrafluoroborate 
• 136667-02-2 α-(o-tolyl)valerophenone 
• 56812-61-4 2-methylbenzylmagnesium bromide 
• 100-47-0 benzonitrile 
• 19348-89-1 diphenyl {[(4-nitrophenyl)amino](phenyl)methyl}phosphonate 
• 529-20-4 2-methylphenyl aldehyde 
• 59305-26-9 o-xylyllithium 
• 65-85-0 benzoic acid 
• 644-36-0 o-methylphenylacetic acid 
• 14309-60-5 1-phenylethynyltoluene 

Downstream Products

• 72292-01-4 (2-(2-methylphenyl)ethene-1,1-diyl)dibenzene 
• 5033-72-7 α-Brom-α-o-tolyl-acetophenon 
• 92548-78-2 2-hydroxy-2-phenylindan 
• 77989-08-3 3-phenyl-4-o-tolyl-1,2,5-thiadiazole 
• 136667-02-2 α-(o-tolyl)valerophenone 
• 129448-68-6 1-phenyl-2-(2-methylphenyl)-3-(3-methoxyphenyl)-1-propanone 
• 53423-27-1 2-(2-methylphenyl)-1-phenylpropan-1-one 
• 41605-84-9 3-Methyl-2-phenyl-1-o-tolyl-propen-2 
• 53443-94-0 (Z)-1-methyl-2-(2-phenylbut-1-enyl)benzene 
• 53443-95-1 (E)-1-methyl-2-(2-phenylbut-1-enyl)benzene 
• 53423-26-0 (Z)-2,α'-Dimethylstilben 
• 34260-58-7 (E)-2,α'-Dimethylstilben 
• 41605-74-7 2-Phenyl-3-(o-tolyl)-propen 
• 16216-14-1 o-methylbenzil 

Relevant articles and documents

H2O2-mediated room temperature synthesis of 2-arylacetophenones from arylhydrazines and vinyl azides in water

An environmentally benign, cost-efficient and practical methodology for the room temperature synthesis of 2-arylacetophenones in water has been discovered. The facile and efficient transformation involves the oxidative radical addition of arylhydrazines with α-aryl vinyl azides in the presence of H2O2 (as a radical initiator) and PEG-800 (as a phase-transfer catalyst). From the viewpoint of green chemistry and organic synthesis, the present protocol is of great significance because of using cheap, non-toxic and readily available starting materials and reagents as well as amenability to gram-scale synthesis, which provides an attractive strategy to access 2-arylacetophenones.

Aerobic oxygenation of α-methylene ketones under visible-light catalysed by a CeNi3complex with a macrocyclic tris(salen)-ligand

A hetero-tetranuclear CeNi3 complex with a macrocyclic ligand catalysed the aerobic oxygenation of a methylene group adjacent to a carbonyl group under visible-light radiation to produce the corresponding α-diketones. The visible-light induced homolysis of the Ce-O bond of a bis(enolate) intermediate is proposed prior to aerobic oxygenation.

Palladium-catalyzed synthesis of α-aryl acetophenones from styryl ethers and aryl diazonium saltsviaregioselective Heck arylation at room temperature

Preparation of α-aryl acetophenones from styryl ethers and aryldiazonium salts is described. The reaction is catalyzed by palladium acetate at room temperature in the absence of ligand and base. The developed method is highly attractive in terms of reaction conditions, substrate scope, functional group tolerance and yields. Synthetic applications of the present method are demonstrated by preparing α-aryl indoles and 3-aryl isocoumarin from styryl ethers.