503817-57-0

Basic information

• Product Name: Cyclohexanecarboxylic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester
• Synonyms: methyl 4-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylate
• CAS NO: 503817-57-0
• Molecular Formula: C13H23NO4
• Molecular Weight: 257.33
• Mol File: 503817-57-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Cyclohexanecarboxylic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarboxylic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester(503817-57-0)
• EPA Substance Registry System: Cyclohexanecarboxylic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester(503817-57-0)

Safety Data

• Hazardous Substances Data: 503817-57-0(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 67-56-1 methanol 
• 130309-46-5 trans-4-(tert-butoxycarbonylamino)cyclohexane carboxylic acid 
• 186581-53-3 diazomethane 
• 6297-22-9 4-carbomethoxycyclohexanone 
• 874-61-3 4-oxocyclohexanecarboxylic acid 
• 175867-59-1 methyl 4-aminocyclohexane-1-carboxylate 
• 1776-53-0 4-aminocyclohexanecarboxylic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 130309-46-5 trans-4-(tert-butoxycarbonylamino)cyclohexane carboxylic acid 
• 1350550-50-3 tert-butyl 4-(bromomethyl)cyclohexylcarbamate 

Relevant articles and documents

Preparation method of trans 4 - (tert-butyloxycarbonylamino) cyclohexanecarboxylic acid and intermediate thereof

The invention provides a preparation method of trans 4 - (tert-butyloxycarbonylamino) cyclohexanecarboxylic acid and an intermediate thereof. The preparation method is characterized by comprising the following steps of 4 - oxocyclohexane carboxylic ester and chiral ligand reagent tert-butyl sulfinamide as a raw material, reducing amination to obtain trans -4 -tert-butyl sulfinyl sulfenamide cyclohexane carboxylic acid ester by virtue of chiral ligand reagent tert-butyl sulfinamide and 4 - 95% -oxocyclohexane carboxylic ester, and is stable in basic conditions and easy to leave under an acidic condition. Reaction conditions are mild, operation is simple and convenient, yield is high, and industrial production is easy.

POLYCYCLIC AMINES AS OPIOID RECEPTOR MODULATORS

The present invention provides a genus of polycyclic amines that are useful as opioid receptor modulators. The compounds of the invention are useful in both therapeutic and diagnostic methods, including for treating pain, neurological disorders, cardiac disorders, bowel disorders, drug and alcohol addiction, drug overdose, urinary disorders, respiratory disorders, sexual dysfunction, psoriasis, graft rejection or cancer.

DOPAMINE D3 RECEPTOR ANTAGONISTS COMPOUNDS

The disclosure is directed to novel dopamine D3 receptor antagonists, processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, including treating drug dependency and psychosis.