50390-68-6Relevant articles and documents
The Asymmetric Cyclisation of Substituted Pent-4-enals by a Chiral Rhodium Phosphine Catalyst
James, Brian R.,Young, Charles G.
, p. 1215 - 1216 (1983)
Treatment of the racemic disubstituted pent-4-enals (1) and (2) at ca. 150 deg C with the chiral complex Cl results in a cyclisation reaction and catalytic asymmetric synthesis of the 2,2- and 3,3-disubstituted cyclopentanones (3) and (4), respectively.
Enantioselective Intramolecular Hydroacylation of Unactivated Alkenes: An NHC-Catalyzed Robust and Versatile Formation of Cyclic Chiral Ketones
Janssen-Müller, Daniel,Schedler, Michael,Fleige, Mirco,Daniliuc, Constantin G.,Glorius, Frank
supporting information, p. 12492 - 12496 (2015/10/12)
A highly enantioselective intramolecular N-heterocyclic carbene (NHC)-catalyzed hydroacylation reaction gives access to a range of cyclic ketones from unactivated olefin-substituted aldehydes (up to 99% ee). Remarkably, aliphatic aldehydes were also transformed efficiently in an NHC-catalyzed hydroacylation reaction for the first time. 100% Organic: A highly enantioselective N-heterocyclic carbene (NHC)-catalyzed intramolecular hydroacylation of aromatic and, more interestingly, aliphatic aldehydes with unactivated olefins offers access to a range of cyclic α-chiral ketones bearing quaternary centers. The reaction was found to be highly robust and proceeds with excellent yield in the presence of a diverse range of functional groups.
COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION
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, (2012/08/08)
The present disclosure provides a series of compounds of the formula (I), which modulate β-amyloid peptide (β-ΑΡ) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-ΑΡ) production.