50488-42-1 Usage
Description
2-Bromo-5-(trifluoromethyl)pyridine is an organic compound characterized by its light yellow needle-like crystalline structure. It features a pyridine ring with a bromine atom at the 2nd position and a trifluoromethyl group at the 5th position, which contributes to its unique chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
2-Bromo-5-(trifluoromethyl)pyridine is used as a substrate for the palladium-catalyzed α-arylation of a Reformatsky reagent. This reaction is significant in the synthesis of various pharmaceutical compounds, as it allows for the formation of new carbon-carbon bonds, which are essential in constructing complex molecular structures.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-Bromo-5-(trifluoromethyl)pyridine serves as a valuable building block for creating a wide range of organic molecules. Its unique functional groups and reactivity make it a versatile starting material for the development of new compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Chemical Properties:
The chemical properties of 2-Bromo-5-(trifluoromethyl)pyridine include its light yellow needle-like crystalline appearance, which is indicative of its solid-state structure. The presence of the bromine and trifluoromethyl groups on the pyridine ring endows the molecule with specific reactivity and stability, making it a useful compound for various chemical transformations and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 50488-42-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,4,8 and 8 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 50488-42:
(7*5)+(6*0)+(5*4)+(4*8)+(3*8)+(2*4)+(1*2)=121
121 % 10 = 1
So 50488-42-1 is a valid CAS Registry Number.
InChI:InChI=1/C13H8F2O2/c14-11-6-5-10(7-12(11)15)8-1-3-9(4-2-8)13(16)17/h1-7H,(H,16,17)
50488-42-1Relevant articles and documents
Recommendable routes to trifluoromethyl-substituted pyridine- and quinolinecarboxylic acids
Cottet, Fabrice,Marull, Marc,Lefebvre, Olivier,Schlosser, Manfred
, p. 1559 - 1568 (2007/10/03)
As part of a case study, rational strategies for the preparation of all ten 2-, 3-, or 4-pyridinecarboxylic acids and all nine 2-, 3-, 4-, or 8-quinolinecarboxylic acids bearing trifluoromethyl substituents at the 2-, 3-, or 4-position were elaborated. The trifluoromethyl group, if not already present in the precursor, was introduced either by the deoxygenative fluorination of suitable carboxylic acids with sulfur tetrafluoride or by the displacement of ring-bound bromine or iodine by trifluoromethylcopper generated in situ. The carboxy function was produced by treatment of organolithium or organomagnesium intermediates, products of halogen/metal or hydrogen/ metal permutation, with carbon dioxide. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).