50594-66-6Relevant articles and documents
Method for nitration synthesis of acifluorfen in microreactor
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Paragraph 0021-0036, (2021/02/13)
The invention relates to a method for nitration synthesis of acifluorfen in a microreactor. The method for nitration synthesis of acifluorfen in the microreactor comprises the following steps: proportionally pumping a nitrating agent composed of a solution containing raw materials 3 (2chlorine 4trifluoromethyl phenoxy) benzoic acid, fuming sulfuric acid and fuming nitric acid into the micro-channel reactor in parallel through a metering pump; and reacting to synthesize the 5 (2chlorine 4trifluoromethyl phenoxy) 2nitrobenzoic acid (acifluorfen). The acifluorfen is synthesized by nitration of the micro-channel reactor, the phase contact area is increased, and the mass transfer rate and the reaction rate are high; The heat transfer efficiency is increased, reaction heat is transferred quickly, and safety is improved; The continuous operation is achieved, product quality is stable, operation is flexible, and amplification is easy; under optimized conditions, the reaction conversion rate can reach 99.19%, and the reaction selectivity is 81.08%.
Preparation method of fomesafenbulk drug intermediate acifluorfen
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Paragraph 0028-0047, (2020/09/12)
The invention provides a preparation method of fomesafenbulk drug intermediate acifluorfen, and belongs to the technical field of pesticides. According to the method, a low-temperature nitrification mode is adopted,nitrylions can be slowly released, so that the reaction tends to be gentle, the selective competitiveness of a target product is enhanced, polynitrification and ectopic nitrification byproducts are inhibited, and the content of the intermediate acifluorfen is effectively increased. The method provided by the invention can be effectively applied to production and application of the fomesafen technical.
METHOD FOR THE NITRATION OF SUBSTITUTED BENZENES IN THE PRESENCE OF PROPIONIC ACID
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Page/Page column 2, (2011/01/11)
The aim of the invention is to provide a widely applicable method for the nitration of substituted benzenes.