50638-48-7 Usage
Description
4-Bromo-2,3-dimethylanisole is an organic compound derived from anisole, characterized by the presence of a bromine atom at the 4th position and two methyl groups at the 2nd and 3rd positions. It can be synthesized from 2,3-dimethylanisole through bromination using the N-bromosuccinimide-acetonitrile (NBS-CH3CN) system.
Uses
Used in Chemical Synthesis:
4-Bromo-2,3-dimethylanisole is used as a chemical intermediate for the preparation of various compounds, including:
1. 4,6-Dibromo-2,3-dimethylanisole: It is used as a precursor in the synthesis of this compound through bromination using the NBS-CH3CN system.
2. 4-Methoxy-2,2′,3,3′-tetramethyldiphenyl ether: It serves as a starting material in the reaction with 2,3-dimethylphenol to produce this specific compound.
3. Arylsulfonamide Derivatives: 4-Bromo-2,3-dimethylanisole is utilized in the synthesis of novel arylsulfonamide derivatives, which exhibit potent glucocorticoid receptor (GR) agonist activity, potentially useful in the pharmaceutical industry for developing new drugs targeting GR-related conditions.
Used in Pharmaceutical Industry:
4-Bromo-2,3-dimethylanisole is used as a key intermediate in the development of arylsulfonamide derivatives with potent glucocorticoid receptor agonist activity. These derivatives have potential applications in the treatment of various medical conditions, such as inflammation, autoimmune diseases, and other GR-related disorders, due to their ability to modulate the activity of the glucocorticoid receptor.
Check Digit Verification of cas no
The CAS Registry Mumber 50638-48-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,6,3 and 8 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 50638-48:
(7*5)+(6*0)+(5*6)+(4*3)+(3*8)+(2*4)+(1*8)=117
117 % 10 = 7
So 50638-48-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H11BrO/c1-6-7(2)9(11-3)5-4-8(6)10/h4-5H,1-3H3
50638-48-7Relevant articles and documents
Highly Regioselective Bromination of 2,3-dimethylanisole with N-Bromosuccinimide
Goldberg, Yuri,Bensimon, Corrine,Alper, Howard
, p. 6374 - 6376 (1992)
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CXCR3 RECEPTOR AGONISTS
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Paragraph 315, (2018/03/25)
Compounds are provided having the structure of the following Formula I: where R, R1, R2, R3a and R3b are as defined herein. Pharmaceutical compositions comprising such compounds, as well as methods related to their manufacture and use, are also provided.
Nickel-catalyzed decarbonylative polymerization of 5-alkynylphthalimides: A new methodology for the preparation of polyheterocycles
Takeuchi, Makoto,Kurahashi, Takuya,Matsubara, Seijiro
supporting information, p. 1566 - 1568 (2013/01/15)
A nickel-catalyzed decarbonylative cycloaddition was developed, in which 5-alkynylphthalimides reacted to afford a new type of polyisoquinolone. It was demonstrated for the first time that decarbonylative cycloaddition can be an elementary process of polycondensation for the preparation of heterocyclic polymers.
