50650-59-4

Basic information

• Product Name: 2-Hydroxy-4-(trifluoromethyl)pyridine
• Synonyms: BUTTPARK 45\01-79;4-(TRIFLUOROMETHYL)-2-PYRIDONE;4-(TRIFLUOROMETHYL)PYRIDIN-2-OL;4-TRIFLUOROMETHYL-2(1H)PYRIDINONE;2-HYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE;2-hydroxy-4-(tridluoromethyl)pyridine;4-(Trifluoromethyl)pyridin-2-one;4-(Trifluoromethyl)pyridin-2-ol, 4-(Trifluoromethyl)pyridin-2(1H)-one
• CAS NO: 50650-59-4
• Molecular Formula: C₆H₄F₃NO
• Molecular Weight: 163.1
• EINECS: 1312995-182-4
• Product Categories: Pyridine;Pyridines;Heterocycle;Pyridine series;C6;Heterocyclic Building Blocks;Fluorine series
• Mol File: 50650-59-4.mol
• Article Data: 11

Chemical Properties

• Melting Point: 161-165 °C(lit.)
• Boiling Point: 221.2 °C at 760 mmHg
• Flash Point: 87.6 °C
• Appearance: /
• Density: 1.398 g/cm³
• Vapor Pressure: 0.108mmHg at 25°C
• Refractive Index: 1.436
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Soluble in methanol.
• PKA: 10.76±0.10(Predicted)
• CAS DataBase Reference: 2-Hydroxy-4-(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-4-(trifluoromethyl)pyridine(50650-59-4)
• EPA Substance Registry System: 2-Hydroxy-4-(trifluoromethyl)pyridine(50650-59-4)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-37/38-41
• Safety Statements: 26-36-39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 50650-59-4(Hazardous Substances Data)

Usage

Description

2-Hydroxy-4-(trifluoromethyl)pyridine is a white solid chemical compound characterized by its unique molecular structure featuring a hydroxyl group at the 2nd position and a trifluoromethyl group at the 4th position on a pyridine ring. 2-Hydroxy-4-(trifluoromethyl)pyridine is known for its versatile chemical properties and potential applications in various industries.

Uses

Used in Pharmaceutical Industry:
2-Hydroxy-4-(trifluoromethyl)pyridine is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications, making it a valuable component in the medicinal chemistry field.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Hydroxy-4-(trifluoromethyl)pyridine is utilized as a key building block for the creation of novel agrochemicals. Its incorporation into these products can enhance their effectiveness in areas such as pest control, crop protection, and overall agricultural yield improvement.
Chemical Properties:
As a white solid, 2-Hydroxy-4-(trifluoromethyl)pyridine exhibits distinct chemical properties that make it suitable for a range of applications. Its stability and reactivity contribute to its usefulness in the synthesis of various compounds, particularly in the pharmaceutical and agrochemical sectors.

InChI:InChI=1/C6H4F3NO/c7-6(8,9)4-1-2-10-5(11)3-4/h1-3H,(H,10,11)

Upstream product

• 106447-97-6 2-amino-4-(trifluoromethyl)pyridine 
• 59938-06-6 (E)-4-Ethoxy-1,1,1-trifluoro-3-buten-2-one 
• 107-14-2 chloroacetonitrile 
• 81565-18-6 2-chloro-4-trifluoromethyl pyridine 
• 67-56-1 methanol 
• 354-32-5 trifluoracetyl chloride 
• 5927-18-4 trimethyl phosphonoacetate 
• 109-92-2 ethyl vinyl ether 
• 1095142-51-0 C₆H₉F₃O₃ 
• 1095142-53-2 C₇H₁₃F₃O₄ 
• 1095142-55-4 C₈H₁₅F₃O₄ 
• 59938-06-6 4-ethoxy-1,1,1-trifluoro-3-butene-2-one 
• 75-77-4 chloro-trimethyl-silane 
• 22282-72-0 2-oxo-1,2-dihydropyridine-4-carboxylic acid 

Downstream Products

• 121307-79-7 4-trifluoromethylpyridine-2(1H)-thione 
• 81565-18-6 2-chloro-4-trifluoromethyl pyridine 
• 390412-38-1 2,5-difluoro-4-[2-oxo-4-(trifluoromethyl)-1-(2H)-pyridinyl]benzonitrile 
• 109919-31-5 5-chloro-4-trifluoromethyl-2-pyridone 
• 109919-32-6 5-bromo-4-(trifluoromethyl)pyridin-2(1H)-one 
• 1449746-99-9 CYM-5491 
• 1105689-98-2 N-benzyl-4-methyl-2-(2-oxo-4-(trifluoromethyl)pyridin-1(2H)-yl)thiazole-5-carboxamide 
• 1544740-01-3 (5aR,6S,6aS)-ethyl 3-((3-(6-(2-hydroxy-2-methylpropoxy)-4-(trifluoromethyl)pyridin-3-yl) benzyl)oxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate 
• 1544739-97-0 (5aR,6S,6aS)-3-((3-(6-(2-hydroxy-2-methylpropoxy)-4-(trifluoromethyl)pyridin-3-yl)benzyl)oxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid 
• 1544740-48-8 (5aR,6S,6aS)-ethyl 3-((2-fluoro-5-(6-((4-hydroxy-4-methylpentyl)oxy)-4-(trifluoromethyl)pyridin-3-yl) benzyl)oxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate 
• 1544740-44-4 (5aR,6S,6aS)-3-((2-fluoro-5-(6-((4-hydroxy-4-methylpentyl)oxy)-4-(trifluoromethyl)pyridin-3-yl) benzyl)oxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid 

Relevant articles and documents

Discovery and characterization of a novel perylenephotoreductant for the activation of aryl halides

To develop a photocatalyst with catalytical activity for substrates with low reactivities is always highly desired. Herein, based on the principle of structure–property relationships, we rationally designed the natural product cercosporin, the naturally occurring perylenequinonoid pigment, to develop a novel organic perylenephotoreductant, hexacetyl reduced cercosporin (HARCP), through structural manipulation. Compared with cercosporin, HARCP shows prominent electrochemical and photophysical characteristics with greatly improved photoreductive activity, fluorescence lifetime and fluorescence quantum yield. These properties allowed HARCP as a powerful photoreductant to efficiently realize a series of benchmark reactions, including photoreduction, alkoxylation and hydroxylation to construct C–H and C–O bonds using aryl halides as substrates under mild conditions, all of which have never been achieved by the same photocatalyst. Thus, this study well supports the notion that the principle between structural manipulation and photocatalytic activity is of great significance to design customized photocatalysts for photoredox chemistry.

ANTIDIABETIC TRICYCLIC COMPOUNDS

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS

Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.