50670-51-4

Basic information

• Product Name: 4'-(BROMOMETHYL)-[1,1'-BIPHENYL]-4-CARBONITRILE
• Synonyms: 4'-(BROMOMETHYL)-[1,1'-BIPHENYL]-4-CARBONITRILE;4'-BroMoMethyl-biphenyl-4-carbonitrile;1-(broMoMethyl)-4-phenylcyclohexa-2,4-diene-1-carbonitrile;4-(broMoMethyl)-4'-cyanobiphenyl
• CAS NO: 50670-51-4
• Molecular Formula: C₁₄H₁₀BrN
• Molecular Weight: 272.1399
• Mol File: 50670-51-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 400.074 °C at 760 mmHg
• Flash Point: 195.758 °C
• Appearance: /
• Density: 1.435 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4'-(BROMOMETHYL)-[1,1'-BIPHENYL]-4-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-(BROMOMETHYL)-[1,1'-BIPHENYL]-4-CARBONITRILE(50670-51-4)
• EPA Substance Registry System: 4'-(BROMOMETHYL)-[1,1'-BIPHENYL]-4-CARBONITRILE(50670-51-4)

Safety Data

• Hazardous Substances Data: 50670-51-4(Hazardous Substances Data)

Usage

General Description

4'-(Bromomethyl)-[1,1'-biphenyl]-4-carbonitrile is a chemical compound with the molecular formula C14H9BrN. It is a biphenyl derivative with a bromomethyl group and a carbonitrile group attached to the 4th carbon of the biphenyl ring. 4'-(BROMOMETHYL)-[1,1'-BIPHENYL]-4-CARBONITRILE is commonly used in organic synthesis and pharmaceutical research as a building block and intermediate for the synthesis of other complex organic compounds. It can also be used in the production of materials and chemicals for various industrial applications. 4'-(Bromomethyl)-[1,1'-biphenyl]-4-carbonitrile is a versatile compound with potential uses in a variety of fields including chemistry, materials science, and pharmaceuticals.

Upstream product

• 50670-50-3 p-(p-tolyl)benzonitrile 
• 106-38-7 para-bromotoluene 
• 623-00-7 4-bromobenzenecarbonitrile 
• 154493-59-1 4-Cyano-4'-hydroxymethyl-biphenyl 
• 5720-05-8 4-methylphenylboronic acid 

Downstream Products

• 1207618-20-9 ethyl 1-[5-chloro-4-(2-{[(4'-cyano-4-biphenylyl)methyl]oxy}phenyl)-1,3-thiazol-2-yl]-4-piperidinecarboxylate 
• 1417334-70-3 C₂₄H₁₇N₃O₃S 

Relevant articles and documents

Structure-based optimization of oxadiazole-based GSK-3 inhibitors

Inhibition of glycogen synthase kinase-3 (GSK-3) induces neuroprotective effects, e.g. decreases β-amyloid production and reduces tau hyperphosphorylation, which are both associated with Alzheimer's disease (AD). The two isoforms of GSK-3 in mammalians are GSK-3α and β, which share 98% homology in their catalytic domains. We investigated GSK-3 inhibitors based on 2 different scaffolds in order to elucidate the demands of the ATP-binding pocket [1]. Particularly, the oxadiazole scaffold provided potent and selective GSK-3 inhibitors. For example, the most potent inhibitor of the present series, the acetamide 26d, is characterized by an IC50 of 2 nM for GSK-3α and 17 nM for GSK-3β. In addition, the benzodioxane 8g showed up to 27-fold selectivity for GSK-3α over GSK-3β, with an IC 50 of 35 nM for GSK-3α. Two GSK-3 inhibitors were further profiled for efficacy and toxicity in the wild-type (wt) zebrafish embryo assay to evaluate simultaneously permeability and safety.

THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE

Disclosed are compounds of formula (I) wherein R1 and R2 are independently selected from hydrogen, halo, C1-4alkyl, C1-4alkoxy, CF3 and OCF3; -Y- represents formula (IA) R3 represents hydrogen, fluoro, chloro or C1-4alkyl; R4a and R4b each independently represent hydrogen, C1-4alkyl, C1-4alkoxy, CF3 or halo; and R5 represents a group Z-X; wherein Z is absent or represents (CH2)2 or O; and X represents formula (IB) wherein: J and L both represent CH, or one of J and L represents CH and the other represents N; when both J and L represent CH, R6 represents hydrogen, halo, CF3, C1-4alkyl or C1-4alkoxy in a meta or ortho position relative to the R7 substituent and R7 represents hydrogen, halo, CF3, OCF3, C1-4alkyl, C1-4alkoxy, CH2OH, CN, CONR8R9 or CO2H; or when one of J or L represents N, R6 represents hydrogen or halo in a meta or ortho position relative to the R7 substituent and R7 represents hydrogen, halo, CF3, C1-4alkyl, C1-4alkoxy, CH2OH, CN, CONR8R9 or CO2H; and R8 and R9 are independently selected from hydrogen and C1-4alkyl; or salts thereof which activate soluble guanylate cyclase (sGC), pharmaceutical compositions containing them, their use in medicine, and processes for their preparation.

2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS

Disclosed are compounds of formula (I) wherein R1 and R2 are independently selected from hydrogen, halo, CF3, C1-4alkyl and allyl; Y represents (II), (III), (IV) or (V) wherein R3 represents CF3 or C1-4alkyl; and R3a represents CF3 or C1-4alkyl.