50772-59-3

Basic information

• Product Name: 2-Chloro-N-(5-nitro-thiazol-2-yl)-acetaMide, 98+% C5H4ClN3O3S, MW: 221.62
• Synonyms: 2-Chloro-N-(5-nitro-thiazol-2-yl)-acetaMide, 98+% C5H4ClN3O3S, MW: 221.62;2-(2-Chloroacetamido)-5-nitrothiazole;2-Chloro-N-(5-nitro-2-thiazolyl)acetamide;NSC 149458;2-chloro-N-(5-nitro-1,3-thiazol-2-yl)acetamide
• CAS NO: 50772-59-3
• Molecular Formula: C₅H₄ClN₃O₃S
• Molecular Weight: 221.62156
• Mol File: 50772-59-3.mol
• Article Data: 15

Chemical Properties

• Melting Point: 146-147℃
• Appearance: /
• Density: 1.725
• Refractive Index: 1.677
• CAS DataBase Reference: 2-Chloro-N-(5-nitro-thiazol-2-yl)-acetaMide, 98+% C5H4ClN3O3S, MW: 221.62(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-N-(5-nitro-thiazol-2-yl)-acetaMide, 98+% C5H4ClN3O3S, MW: 221.62(50772-59-3)
• EPA Substance Registry System: 2-Chloro-N-(5-nitro-thiazol-2-yl)-acetaMide, 98+% C5H4ClN3O3S, MW: 221.62(50772-59-3)

Safety Data

• Hazardous Substances Data: 50772-59-3(Hazardous Substances Data)

Usage

Description

2-Chloro-N-(5-nitro-thiazol-2-yl)-acetaMide, 98+% C5H4ClN3O3S, MW: 221.62 is a nitro-thiazole derivative chemical compound with a molecular formula of C5H4ClN3O3S and a molecular weight of 221.62. It contains a chlorine atom and an acetamide group, and is known for its anti-inflammatory and anti-microbial properties. With a purity of 98% or higher, it is commonly used as a reagent in organic synthesis and as a starting material for the production of various pharmaceuticals and agrochemicals. Its high purity and stable properties make it a valuable compound for scientific and industrial applications.
Used in Pharmaceutical Industry:
2-Chloro-N-(5-nitro-thiazol-2-yl)-acetaMide, 98+% C5H4ClN3O3S, MW: 221.62 is used as a starting material for the production of various pharmaceuticals due to its anti-inflammatory and anti-microbial properties.
Used in Agrochemical Industry:
2-Chloro-N-(5-nitro-thiazol-2-yl)-acetaMide, 98+% C5H4ClN3O3S, MW: 221.62 is used as a starting material for the production of various agrochemicals, taking advantage of its anti-microbial properties to protect crops and enhance agricultural productivity.
Used in Organic Synthesis:
2-Chloro-N-(5-nitro-thiazol-2-yl)-acetaMide, 98+% C5H4ClN3O3S, MW: 221.62 is used as a reagent in organic synthesis, contributing to the development of new compounds and materials with potential applications in various industries.

InChI:InChI=1/C5H4ClN3O3S/c6-1-3(10)8-5-7-2-4(13-5)9(11)12/h2H,1H2,(H,7,8,10)

Upstream product

• 121-66-4 2-amino-5-nitro-1,3-thiazole 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 1228763-97-0 (Z)-2-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-N-(5-nitrothiazol-2-yl)acetamide 

Relevant articles and documents

Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds

A small series of 5-nitro-2-aminothiazole-based amides containing arylpiperazine-, biphenyl- or aryloxyphenyl groups in their core were synthesized and evaluated as antitrypanosomatid agents. All tested compounds were active or moderately active against T

An extensive research on aldose reductase inhibitory effects of new 4H-1,2,4-triazole derivatives

Aldose reductase (AR) is a key enzyme, which triggers the excessive accumulation of sorbitol in insulin independent tissues leading to severe diabetes-induced microvascular complications. Substantial evidence has proven that AR inhibition is a well-establ

Design, synthesis, and biological evaluation of novel 1,3,4-thiadiazole derivatives as potential antitumor agents against chronic myelogenous leukemia: Striking effect of nitrothiazole moiety

In an attempt to develop potent antitumor agents, new 1,3,4-thiadiazole derivatives were synthesized and evaluated for their cytotoxic effects on multiple human cancer cell lines, including the K562 chronic myelogenous leukemia cell line that expresses the Bcr-Abl tyrosine kinase. N-(5-Nitrothiazol-2-yl)-2-((5-((4-(trifluoromethyl)phenyl)amino)-1,3,4-thiadiazol-2-yl)thio)acetamide (2) inhibited the Abl protein kinase with an IC50 value of 7.4 μM and showed selective activity against the Bcr-Abl positive K562 cell line. Furthermore, a Bcr-Abl-compound 2 molecular modelling simulation highlighted the anchoring role of the nitrothiazole moiety in bonding and hydrophobic interaction with the key amino acid residues. These results provide promising starting points for further development of novel kinase inhibitors.

ANTIBACTERIAL THERAPEUTICS AND PROPHYLACTICS

The present disclosure relates generally to novel molecules, compositions, and formulations for treatment of bacterial infections in general and more specifically to bacterial infections with antibiotic resistant pathogens.