50873-93-3

Basic information

• Product Name: 1-(BENZYLOXY)-4-CHLOROBUTANE
• Synonyms: 1-(BENZYLOXY)-4-CHLOROBUTANE;Ether, 4-chlorobutyl o-tolyl,;Benzyl 4-chlorobutyl ether;Benzyl(4-chlorobutyl) ether
• CAS NO: 50873-93-3
• Molecular Formula: C₁₁H₁₅ClO
• Molecular Weight: 198.69
• Mol File: 50873-93-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 286.7°Cat760mmHg
• Flash Point: 129.8°C
• Appearance: /
• Density: 1.042g/cm³
• CAS DataBase Reference: 1-(BENZYLOXY)-4-CHLOROBUTANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(BENZYLOXY)-4-CHLOROBUTANE(50873-93-3)
• EPA Substance Registry System: 1-(BENZYLOXY)-4-CHLOROBUTANE(50873-93-3)

Safety Data

• Hazardous Substances Data: 50873-93-3(Hazardous Substances Data)

Usage

Physical state

Clear, colorless liquid

Molecular weight

204.69 g/mol

Usage

Intermediate in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals

Chemical classification

Alkyl halide (due to the presence of a chlorine atom attached to a butane chain)

Functional groups

Contains a benzyl ether group

Flammability

Flammable

Hazardous properties

May be harmful if swallowed, inhaled, or absorbed through the skin

Safety handling

Should be handled with care and in accordance with proper safety protocols

Upstream product

• 4541-14-4 4-benzyloxy-butan-1-ol 
• 109-99-9 tetrahydrofuran 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 
• 928-51-8 4-Chloro-1-butanol 
• 55791-06-5 benzyl mesylate 
• 6940-78-9 4-chlorobutyl bromide 
• 100-51-6 benzyl alcohol 
• 17229-17-3 benzyl 2-chloroethyl ether 
• 4799-68-2 3-benzyloxypropan-1-ol 
• 26420-79-1 1-chloro-3-benzyloxypropane 
• 41478-45-9 Diethyl<(2-benzyloxy)ethyl>malonate 
• 10385-30-5 4-(benzyloxy)butanoic acid 
• 85174-51-2 4-(benzyloxy)butyronitrile 

Downstream Products

• 856061-94-4 bis-(4-benzyloxy-butyl)-sulfide 
• 134005-36-0 (S)-1,8-di-O-benzyl-1,3,8-octanetriol 
• 134005-37-1 (R)-1,8-di-O-benzyl-1,3,8-octanetriol 
• 50873-94-4 (4-iodobutoxymethyl)benzene 
• 78518-93-1 5-(p-Tolyl)-hexanal 
• 91477-32-6 5-(Benzyloxy)pentane nitrile 
• 836-27-1 1,3-dimethoxy-5-(5-hydroxypentyl)benzene 
• 110050-09-4 2-(4-benzyloxy-butyl)-1-methyl-1,2,3,4-tetrahydro-isoquinoline 
• 134834-30-3 (1S,2R)-2--N-butylamino>-1-phenylpropan-1-ol 
• 100847-48-1 5-benzyloxy-1-(furan-3'-yl)pentan-1-ol 
• 134834-37-0 (1S,2R)-N-C₆H₅CH₂O(CH₂)4-N-methylnorephedrine 
• 68677-52-1 7-benzyloxy-1-(1,3-dithia-2-cyclopentyl)-heptane-3-one 
• 1221503-08-7 [4-(benzyloxy)butyl]hydrazine hydrochloride 
• 1221503-10-1 1-[4-(benzyloxy)butyl]-5-(4-fluorophenyl)-3-methyl-1Hpyrazole 

Relevant articles and documents

Synthesis and pharmacological evaluation of benzamide derivatives as selective 5-HT4 receptor agonists

It is thought that selective 5-HT4 receptor agonists-such as 4-amino-5-chloro-2-methoxy-N-[1-(6-oxo-6-phenylhexyl)piperidin-4-ylmethyl] benzamide (2)-have the ability to enhance both upper and lower gastrointestinal motility without any significant adverse effects. Modification of 2 was performed. Variation of the piperidin-4-ylmethyl moiety of 2 led to a decrease in the binding affinity for the 5-HT4 receptor. Following conversion of the carbonyl group on the benzoyl part to a hydroxyl or sulfoxide group, the binding affinity for the 5-HT4 receptor was retained although the effect on defecation was reduced. Many of the 4-amino-5-chloro-2-methoxy-N- (piperidin-4-ylmethyl)benzamides that had a ether or sulfide moiety in the side-chain part at the 1-position of the piperidine exhibited high affinity for the 5-HT4 receptor. Among these, phenylthio 41c and benzylthio derivative 44 were selective 5-HT4 receptor agonists, and had a similar effect on defecation to compound 2.

Enantioselective Addition of Diethylzinc to Aldehydes using Chiral Polymer Catalysts Possessing a Methylene Spacer

N-Butylnorephedrine supported on polystyrene resin via a six-methylene spacer catalyses the enantioselective addition of diethylzinc to both aromatic and aliphatic aldehydes, providing optically active secondary alcohols in good to high enantiomeric excesses.In the enantioselective addition of diethylzinc to an aliphatic aldehyde, polymer catalyst with a six-methylene spacer is more enantioselective than other previously reported polymer catalysts.

The in-bicyclo[4.4.4]-1-tetradecyl cation: A stable substance with a three-center, two electron C-H-C bond

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