50886-83-4Relevant articles and documents
In situ alkaline media: Synthesis, spectroscopic, morphology and anticancer assignments of some transition metal ion complexes of 1-((2-aminophenylimino) methyl) naphthalen-2-ol Schiff base
Al-Humaidi, Jehan Y.
, p. 190 - 201 (2019)
Four Schiff base complexes of Cu(II), Co(II), Ni(II) and Zn(II) metal ions were synthesized by reaction of 1-((2-aminophenylimino)methyl)naphthalen-2-ol (HL) with metal(II) chloride salts. The geometric structures of these complexes were elucidated based
Double-decker luminescent ytterbium and erbium SMMs with symmetric and asymmetric Schiff base ligands
Gholizadeh Dogaheh, Samira,Khanmohammadi, Hamid,Sa?udo, E. Carolina
, p. 10101 - 10111 (2017)
Multifunctional molecules that respond both to magnetic fields and light are subject of study due to possible applications in fields as diverse as imaging or information processing and storage. In this paper we report visible and NIR emitting single-molec
Zn(II), Ni(II), Cu(II) and Pb(II) complexes of tridentate asymmetrical Schiff base ligands: Synthesis, characterization, properties and biological activity
Sahin, Mustafa,Kocak, Nuriye,Erdenay, Damla,Arslan, Ugur
, p. 400 - 408 (2013)
New asymmetrical tridentate Schiff base ligands were synthesized using 1,2-phenylenediamine, 4-methyl-1,2-phenylenediamine, 2-hydroxy-1-napthaldehyde, 9-anthracenecarboxaldehyde. Schiff base ligands and their metal complexes were synthesised and character
Efficacy of novel schiff base derivatives as antifungal compounds in combination with approved drugs against candida albicans
Malik, Manzoor Ahmad,Lone, Shabir Ahmad,Gull, Parveez,Dar, Ovas Ahmad,Wani, Mohmmad Younus,Ahmad, Aijaz,Hashmi, Athar Adil
, p. 646 - 656 (2019/08/30)
Background: The increasing incidence of fungal infections, especially caused by Candida albicans, and their increasing drug resistance has drastically increased in recent years. Therefore, not only new drugs but also alternative treatment strategies are promptly required. Methods: We previously reported on the synergistic interaction of some azole and non-azole compounds with fluconazole for combination antifungal therapy. In this study, we synthesized some non-azole Schiff-base derivatives and evaluated their antifungal activity profile alone and in combination with the most commonly used antifungal drugs-fluconazole (FLC) and amphotericin B (AmB) against four drug susceptible, three FLC resistant and three AmB resistant clinically isolated Candida albicans strains. To further analyze the mechanism of antifungal action of these compounds, we quantified total sterol contents in FLC-susceptible and resistant C. albicans isolates. Results: A pyrimidine ring-containing derivative SB5 showed the most potent antifungal activity against all the tested strains. After combining these compounds with FLC and AmB, 76% combinations were either synergistic or additive while as the rest of the combinations were indifferent. Interestingly, none of the combinations was antagonistic, either with FLC or AmB. Results interpreted from fractional inhibitory concentration index (FICI) and isobolograms revealed 4-10-fold reduction in MIC values for synergistic combinations. These compounds also inhibit ergosterol biosynthesis in a concentration-dependent manner, supported by the results from docking studies. Conclusion: The results of the studies conducted advocate the potential of these compounds as new antifungal drugs. However, further studies are required to understand the other mechanisms and in vivo efficacy and toxicity of these compounds.
